| 產(chǎn)品編號(hào) | bs-19646R-Gold |
| 英文名稱(chēng)1 | Rabbit Anti-Opn1mw/Gold Conjugated antibody |
| 中文名稱(chēng) | 膠體金標(biāo)記的綠視蛋白敏感CBBM抗體 |
| 別 名 | CBBM; CBD; COD5; Color blindness, deutan; Cone dystrophy 5 (X linked); GCP; GOP; Green cone photoreceptor pigment; Green cone pigment; Green sensitive opsin; Green-sensitive opsin; Medium wave sensitive; Medium wave sensitive opsin 1; Medium-wave-sensitive opsin 1; MGC176615; MGC177321; MGC198468; MGC198469; OPN1MW; OPN1MW1; OPN1MW2; OPSG_HUMAN; Opsin 1 (cone pigments), medium wave sensitive (color blindness, deutan); Opsin 1 (cone pigments), medium wave sensitive 2; Opsin 1 (cone pigments), medium wave sensitive; Photopigment apoprotein. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Opn1mw |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009] Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Subcellular Location: Membrane. Tissue Specificity: The three color pigments are found in the cone photoreceptor cells. Post-translational modifications: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. DISEASE: Defects in OPN1MW are the cause of partial colorblindness deutan series (CBD) [MIM:303800]; also known as deuteranopia. Defects in OPN1MW are a cause of blue cone monochromacy (BCM) [MIM:303700]. A rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia. Defects in OPN1MW are a cause of cone dystrophy type 5 (COD5) [MIM:303700]. A X-linked cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs. Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. Database links: Entrez Gene: 2652 Human Entrez Gene: 728458 Human Entrez Gene: 14539 Mouse Omim: 300821 Human Omim: 303800 Human SwissProt: P04001 Human SwissProt: O35599 Mouse Unigene: 247787 Human Unigene: 571751 Human Unigene: 284825 Mouse Unigene: 81056 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
