| 產(chǎn)品編號(hào) | bs-18572R-AP |
| 英文名稱1 | Rabbit Anti-LYPD3/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的LYPD3蛋白抗體 |
| 別 名 | 1600019D15Rik; 2310061G07Rik; C4.4A; FLJ10525; GPI-anchored metastasis-associated protein C4.4A homolog; GPI-anchored metastasis-associated protein homolog; Ly6/PLAUR domain-containing protein 3; Lypd3; LYPD3_HUMAN; Matrigel-induced gene C4 protein; MIG-C4; OTTHUMP00000125225; OTTHUMP00000218396; OTTHUMP00000218397; SHINC3. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 細(xì)胞膜蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LYPD3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: LYPD3 is a 346 amino acid cell membrane protein that supports cell migration. Implicated in tumor progression and urothelial cell-matrix interactions, LYPD3 is expressed in skin, urothelium and placenta, with weak levels found in peripheral blood mononuclear cells and esophagus. Upregulated in migrating keratinocytes, LYPD3 undergoes post-translational N- and O-glycosylation, and contains two UPAR/Ly6 domains. The gene encoding LYPD3 maps to human chromosome 19q13.31. Chromosome 19 consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families, and Fc receptors (FcRs). Function: Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression. Subunit: Binds laminin-1 and laminin-5. Interacts with LGALS3 By similarity. Interacts with AGR2 and AGR3. Subcellular Location: Cell membrane. Tissue Specificity: Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers. Post-translational modifications: N-glycosylated and O-glycosylated. Similarity: Contains 2 UPAR/Ly6 domains. Database links: Entrez Gene: 27076 Human Omim: 609484 Human SwissProt: O95274 Human Unigene: 631594 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
