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Rabbit Anti-HNF4 gamma/AP Conjugated antibody (bs-18061R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-18061R-AP
英文名稱1 Rabbit Anti-HNF4 gamma/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的肝細(xì)胞核因子4γ抗體
別    名 Hepatocyte nuclear factor 4 gamma; Hepatocyte nuclear factor 4-gamma; HNF 4 gamma; HNF-4-gamma; HNF4G; HNF4G_HUMAN; NR2A2; NR2A3; Nuclear receptor subfamily 2 group A member 2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  糖尿病  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, Cat, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HNF4 gamma
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

Function:
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen.

Similarity:
Belongs to the nuclear hormone receptor family. NR2 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 3174 Human

Entrez Gene: 404168 Cow

Entrez Gene: 100050783 Horse

Entrez Gene: 30942 Mouse

Entrez Gene: 100153753 Pig

Entrez Gene: 365744 Rat

Omim: 605966 Human

SwissProt: Q14541 Human

SwissProt: Q9WUU6 Mouse

Unigene: 241529 Human

Unigene: 330897 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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