| 產(chǎn)品編號 | bs-17874R-BF647 |
| 英文名稱1 | Rabbit Anti-MTG1/GTPBP7/BF647 Conjugated antibody |
| 中文名稱 | BF647標(biāo)記的GTP結(jié)合蛋白7抗體 |
| 別 名 | GTP; GTP binding protein; GTP binding protein 7 (putative); GTP binding protein 7; GTP-binding protein 7 (putative); GTP-binding protein 7; GTPBP7; Mitochondrial GTPase 1; mitochondrial GTPase 1 homolog (S. cerevisiae); MTG1; MTG1_HUMAN; OTTHUMP00000020814; OTTHUMP00000046565; RP11 108K14.2; RP11-108K14.2; RP11108K14.2. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 轉(zhuǎn)錄調(diào)節(jié)因子 轉(zhuǎn)運(yùn)蛋白 線粒體 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Cow, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MTG1/GTPBP7 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: MTH1 is a 179 amino acid cytoplasmic protein that is a member of the nudix hydrolase family. Highly expressed in testis, thymus and proliferating blood lymphocytes, MTH1 functions as an antimutagenic that hydrolyzes oxidized purine nucleoside triphosphates to their corresponding monophosphates. Through its ability to enzymatically hydrolyze ATP and GTP to AMP and GMP, respectively, MTH1 prevents misincorporation of GTP into DNA, thus preventing A:T to C:G transversions. The cytoplasmic location of MTH1, along with its antimutagenic capabilities, suggests that it may also be involved in the sanitization of nucleotide pools for both mitochondrial and nuclear genomes. Four isoforms of MTH1 exist—three of which are formed due to alternative splicing events and one of which is formed via a single-nucleotide polymorphism. Overexpression of MTH1 is implicated in prostate and cell lung carcinomas Function: Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit. Subcellular Location: Mitochondrion. Similarity: Belongs to the MMR1/HSR1 GTP-binding protein family. MTG1 subfamily. Contains 1 G (guanine nucleotide-binding) domain. Database links: Entrez Gene: 92170 Human Entrez Gene: 212508 Mouse SwissProt: Q9BT17 Human SwissProt: Q8R2R6 Mouse Unigene: 501578 Human Unigene: 296088 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
