| 產(chǎn)品編號(hào) | bs-15370R-BF555 |
| 英文名稱1 | Rabbit Anti-GPCR MRGX2 /BF555 Conjugated antibody |
| 中文名稱 | BF555標(biāo)記的G蛋白偶聯(lián)受體MRGX2蛋白抗體 |
| 別 名 | Mas-related G-protein coupled receptor member X2; MRGPRX2; MRGX2; MRGX2_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) G蛋白偶聯(lián)受體 新陳代謝 G蛋白信號(hào) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPCR MRGX2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the development and function of nociceptive neurons and may also regulate the sensation or modulation of pain. MRGPRX2, is a 330 amino acid multi-pass membrane protein that functions as an orphan receptor and, like MRGX, is thought to be involved in the function of nociceptive neurons. Expressed in the central nervous system with highest expression in dorsal root ganglia, MRGX2 may also be involved in cortistatin function, possibly playing a role in sleep regulation and cortical function. Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion. Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. Database links: Entrez Gene: 117194 Human Omim: 607228 Human SwissProt: Q96LB1 Human Unigene: 350566 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
