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Rabbit Anti-P311 protein/BF555 Conjugated antibody (bs-0427R-BF555)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0427R-BF555
英文名稱1 Rabbit Anti-P311 protein/BF555 Conjugated antibody
中文名稱 BF555標記的神經(jīng)再生相關蛋白抗體
別    名 C5orf13; Neuronal protein 3.1; PRO1873; Protein p311; Chromosome 5 open reading frame 13; D4S114; PTZ17; NREP_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  細胞生物  神經(jīng)生物學  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 7.9kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human P311 N-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
P311, also called PTZ17, was identified by suppressive subtraction hybridization as potentially involved in smooth muscle (SM) myogenesis., an 8-kDa polypeptide, was previously shown to be highly expressed in invasive glioma cells. P311 is constitutively serine-phosphorylated; decreased phosphorylation is observed in migration-activated glioma cells. The primary amino acid sequence of P311 indicates a putative serine phosphorylation site (S59) near the PEST domain. Site-directed mutagenesis of S59A retarded P311 degradation and induced glioma cell motility. In contrast, S59D mutation resulted in the rapid degradation of P311 and reduced glioma cell migration.

Function:
May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.

Subunit:
Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction (By similarity). Interacts with FLNA.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in lung (at protein level).

Post-translational modifications:
Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.

Database links:

Entrez Gene: 9315 Human

Entrez Gene: 27528 Mouse

Entrez Gene: 338475 Rat

Omim: 607332 Human

SwissProt: Q16612 Human

SwissProt: Q07475 Mouse

SwissProt: Q80Z34 Rat

Unigene: 36053 Human

Unigene: 694860 Human

Unigene: 728773 Human

Unigene: 407415 Mouse

Unigene: 8180 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

P311 protein 還稱:PTZ17 (pentylenetetrazd117)又稱:增生性瘢痕相關蛋白。該蛋白與燒傷后瘢痕增生修復有關。
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