| 產(chǎn)品編號(hào) | bs-7808R-Gold |
| 英文名稱1 | Rabbit Anti-KNTC1/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的著絲點(diǎn)關(guān)聯(lián)蛋白1抗體 |
| 別 名 | HsROD; Kinetochore associated 1; KNTC1; ROD; Rough Deal homolog, centromere/kinetochore protein; KNTC1_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)胞周期蛋白 細(xì)胞分化 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 251kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KNTC1/Kinetochore |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: The kinetochore is the protein structure in eukaryotes which assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis and meiosis. The kinetochore contains two regions: an inner kinetochore, which is tightly associated with the centromere DNA; and an outer kinetochore, which interacts with microtubules. Even the simplest kinetochores consist of more than 45 different proteins, many of which are conserved throughout eukaryote species. Function: Essential component of the mitotic checkpoint, whichprevents cells from prematurely exiting mitosis. Required for theassembly of the dynein-dynactin and MAD1-MAD2 complexes ontokinetochores. Subunit: Interacts with ZW10. This interaction is required forstable association with the kinetochore. Component of the RZZcomplex composed of KNTC1/ROD, ZW10 and ZWILCH. Subcellular Location: Cytoplasm. Nucleus. Chromosome, centromere,kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic patternof localization during the cell cycle. At interphase, uniformlydistributed throughout the cytoplasm and nucleus. By prophase anduntil late stages of prometaphase, a fraction of the total pool isconcentrated at kinetochores. By metaphase, detected atkinetochores, along spindle fibers and most prominently at thepoles. By late anaphase until the end of telophase, no longerdetectable on kinetochores or along spindle fibers, but stillpresent at the spindle poles. Tissue Specificity: High expression in testis. Database links: UniProtKB/Swiss-Prot: P50748.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
