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Rabbit Anti-IASPP/HRP Conjugated antibody (bs-0284R-HRP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0284R-HRP
英文名稱1 Rabbit Anti-IASPP/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標(biāo)記的腫瘤細(xì)胞凋亡ASPP家族的另一個成員抗體
別    名 IASPP; inhibitor of apoptosis stimulating protein of p53; Inhibitor of ASPP protein; NFkB interacting protein 1; NKIP1; PPP1R13B-like protein; PPP1R13L; Protein iASPP; protein phosphatase 1 regulatory (inhibitor) subunit 13 like; RAI; RelA-associated inhibitor; IASPP_HUMAN; RelA-associated inhibitor; Inhibitor of ASPP protein; NFkB-interacting protein 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 89kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IASPP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
iASPP(inhibitor of apoptosis stimulating protein of p53)regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. Belongs to the ASPP family.

Function:
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.

Subunit:
Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73.

Subcellular Location:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear.

Tissue Specificity:
Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.

Similarity:
Belongs to the ASPP family.
Contains 2 ANK repeats.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 10848 Human

Entrez Gene: 333654 Mouse

Omim: 607463 Human

SwissProt: Q8WUF5 Human

SwissProt: Q3TCU2 Mouse

SwissProt: Q5I1X5 Mouse

Unigene: 466937 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IASPP(inhibitory member of the ASPP family) 是新近發(fā)現(xiàn)的高度保守的p53相關(guān)基因, 是細(xì)胞凋亡ASPP家族的另一個成員。
iASPP能夠抑制ASPP1,2的促凋亡作用,其蛋白產(chǎn)物定位于細(xì)胞核內(nèi),具有結(jié)合NF-κB p65亞基和p53功能,進(jìn)而抑制NF-κB的轉(zhuǎn)錄調(diào)節(jié)和p53對凋亡的調(diào)節(jié)功能。
研究者發(fā)現(xiàn)iASPP蛋白,能夠干擾p53基因發(fā)揮正常的促使細(xì)胞死亡的作用。這就意味著iASPP在正常細(xì)胞轉(zhuǎn)化為癌癥細(xì)胞方面起著重要的促進(jìn)作用,即iASPP具有促進(jìn)癌變的功能。表達(dá)位置:細(xì)胞漿,部分細(xì)胞核。
inhibitor of ASPP

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