| 產(chǎn)品編號(hào) | bs-2517R-BF350 |
| 英文名稱1 | Rabbit Anti-CD72/BF350 Conjugated antibody |
| 中文名稱 | BF350標(biāo)記的CD72蛋白抗體 |
| 別 名 | B-cell differentiation antigen CD72; CD72b; LYB2; B cell differentiation antigen CD72; CD72 antigen; CD72 molecule; CD72c; Ly-19; Ly-32; Ly-m19; Lyb-2; Lyb2; LYB2, mouse, homolog of; Lymphocyte antigen 32; MGC108873; CD72_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 干細(xì)胞 細(xì)胞表面分子 糖蛋白 細(xì)胞類型標(biāo)志物 b-淋巴細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Cow, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD72 N-terminus |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: CD72 antigen is a member of the type II integral membrane glycoproteins which includes other related cell surface molecules such as the asialoglycoprotein receptors, CD23 and the Kupffer cell receptor. The function of CD72 is unknown but the exposure of B cells to CD72 antibodies activates a variety of signaling pathways and can induce MHC class II expression and B cell proliferation. CD72 antigen is expressed on all cells of B cell lineage with the exception of plasma cells and weakly on human tissue macrophages. Function: Plays a role in B-cell proliferation and differentiation. Subunit: Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity). Subcellular Location: Membrane; Single-pass type II membrane protein. Tissue Specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells. Post-translational modifications: Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity). Similarity: Contains 1 C-type lectin domain. Database links: Entrez Gene: 971 Human Omim: 107272 Human SwissProt: P21854 Human Unigene: 116481 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD72是一個(gè)重要的B細(xì)胞特異性受體。屬于II型膜內(nèi)糖蛋白成員中的細(xì)胞表面分子非唾液酸糖蛋白受體，雖然其分子功能目前還不清楚，但目前發(fā)現(xiàn)CD72的多態(tài)性與多種腫瘤有關(guān)。 |
