mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
亚洲av网一区二区三区,99热这里只有精品视频在线观看
Rabbit Anti-RAC1 + RAC2/PE-Cy7 Conjugated antibody (bs-6153R-PE-Cy7)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@m.p2b3.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@m.p2b3.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6153R-PE-Cy7
英文名稱1 Rabbit Anti-RAC1 + RAC2/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的G蛋白P21 RAC2抗體
別    名 RAC2_HUMAN; Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; p21-Rac2; EN-7; Gx; HSPC022; RAC1_HUMAN; Ras-related C3 botulinum toxin substrate 1; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1; MIG5; Rac-1; TC-25.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Chicken, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RAC2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013].

Function:
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity.
Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.

Subunit:
nteracts (GTP-bound form preferentially) with PKN2 (via the REM repeats); the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with the GEF proteins PREX1, RASGRF2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM; the interaction requires PAK1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, BAIAP2L1, CYFIP1/SRA-1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2. Interacts with NOXA1. Interacts with ARHGEF2. Interacts with NISCH (By similarity). Interacts with TBC1D2. Interacts with UNKL. Interacts with USP6. Interacts with SPATA13. Interacts with ARHGEF16; mediates activation of RAC1 by EPHA2. Interacts with ITGB4. Interacts with PIP5K1A (By similarity).

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome.

Tissue Specificity:
Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. Its expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.

Post-translational modifications:
AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome.

Similarity:
Belongs to the small GTPase superfamily. Rho family.

Database links:

Entrez Gene: 5879 Human

Entrez Gene: 5880 Human

Entrez Gene: 19353 Mouse

Entrez Gene: 19354 Mouse

Entrez Gene: 363875 Rat

Entrez Gene: 366957 Rat

Omim: 602048 Human

Omim: 602049 Human

SwissProt: P15153 Human

SwissProt: P63000 Human

SwissProt: P63001 Mouse

SwissProt: Q05144 Mouse

SwissProt: Q6RUV5 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.m.p2b3.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
欧美综合亚洲日韩精品区| 日韩精品一区二区三区四区| 日韩精品中文字幕欧美| 国产精品国产三级在线| 色婷婷狠狠久久综合五月| 精品视频亚洲一区二区三区| 蜜臀av国产精品久久久久| 国产在线观看污污污网站| 9久久99久久久免费精品然| 国产无遮挡又污又黄又爽| 91香蕉下载并安装| av毛片在线免费观看| 亚洲欧美中文在线另类| 一区二区三区久久99精品| 日韩精品中文字幕欧美| 四虎国产精品成人免费久久| 日韩无打码一区二区三区| 亚洲欧美日韩在线三区| 久久这里精品国产99丫e6| 国产精品人妻4p一区| 国语自产拍无码精品视频在线| 亚洲永久精品国产来久精品| 国产微拍无码精品一区| 国产资源网中文最新版| 中文亚洲欧美日韩国产| 中文字幕日本一区二区在线观看| 有码无码人妻一区二区| 国产精品毛片大码女人| 白嫩丰满少妇一区二区| 日韩欧美亚洲精品成人| 蜜臀av国产精品久久久久| av中国一区二区三区| 国产日韩欧美中文字幕在线| 精品无码中文字幕在线| 亚洲精品伦理一区二区三区青春| 日本日本乱码伦视频免费| 欧美精品精品一区乱| 日韩精品一区二区亚洲v欧美v日韩| 人妻少妇精品无码专区漫画| 日产国产精品久久久久久| 国产日韩欧美久久综合网|