| 產(chǎn)品編號 | bs-23535R |
| 英文名稱 | Rabbit Anti-IL22BP antibody |
| 中文名稱 | 白介素22受體結(jié)合蛋白抗體 |
| 別 名 | IL22RA2; Interleukin-22 receptor subunit alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; Interleukin-22-binding protein; IL-22BP; IL22BP; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor class-II member 10; Cytokine receptor family type 2, soluble 1; CRF2-S1; ZcytoR16; I22R2_HUMAN. |
| 研究領(lǐng)域 | 免疫學(xué) 細胞表面分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 25kDa |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse IL22BP : 131-230/230 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
There are two isoforms of IL22 RA2 produce by alternative splicing. Isoform 1 may play a role in establishing and maintaining successful pregnancy. Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). It may play an important role as an IL22 antagonist in the regulation of inflammatory responses. Function: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing and maintaining successful pregnancy. Subcellular Location: Secreted. Tissue Specificity: Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. Similarity: Belongs to the type II cytokine receptor family. Contains 3 fibronectin type-III domains. SWISS: Q80XF5 Gene ID: 237310 Database links: Entrez Gene: 116379 Human Omim: 606648 Human SwissProt: Q969J5 Human Unigene: 126891 Human 白介素22結(jié)合蛋白是一種新型的Ⅱ類細胞因子受體家族成員，它能直接結(jié)合IL－22，作為IL－22的拮抗劑，發(fā)揮著多種生物學(xué)功能。 |
| 產(chǎn)品圖片 |
Sample:
Lymph node(Mouse) Lysate at 40 ug
Primary: Anti- IL22BP (bs-23535R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 25 kD
Observed band size: 25 kD
Sample:
Lane 1: Spleen (Mouse) Lysate at 40 ug
Lane 2: Lymph node (Mouse) Lysate at 40 ug
Lane 3: Breast (Mouse) Lysate at 40 ug
Lane 4: Placenta (Mouse) Lysate at 40 ug
Lane 5: Skin (Mouse) Lysate at 40 ug
Lane 6: Spleen (Rat) Lysate at 40 ug
Lane 7: Lymph node (Rat) Lysate at 40 ug
Lane 8: Breast (Rat) Lysate at 40 ug
Lane 9: Skin (Rat) Lysate at 40 ug
Primary: Anti-IL22BP (bs-23535R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 48/44/28 kD
Observed band size: 42 kD
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