| 產(chǎn)品編號(hào) | bs-20788R |
| 英文名稱 | Rabbit Anti-CCR4 antibody |
| 中文名稱 | 細(xì)胞表面趨化因子受體4抗體 |
| 別 名 | CC chemokine receptor 4; chemokine (C-C motif) receptor 4; CC-CKR-4; CCR-4; CD194; CHEMOKINE CC4 RECEPTOR; CHEMR1; ChemR13; CKR4; CMKBR4; HGCN:14099; K5-5; LESTR; MGC151418; MGC88293; nocturnin, Sdf1r; chemokine C C motif receptor 4; ChemR13; CCR4_HUMAN; C-C chemokine receptor type 4; K5-5; CD 194; CD-194. |
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Specific References (1) | bs-20788R has been referenced in 1 publications.
[IF=6.1] Qian-rong Wang. et al. CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF-β/Smad signaling. BIOCHEM PHARMACOL. 2023 Apr;210:115475 FCM,WB,IHC ; Mouse,Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)胞膜受體 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 40kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CCR4: 171-220/360 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008] Function: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells. Post-translational modifications: In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P51679 Gene ID: 1233 Database links: Entrez Gene: 1233 Human Entrez Gene: 12773 Mouse GenBank: NP_005499.1 Human Omim: 604836 Human SwissProt: P51679 Human SwissProt: P51680 Mouse Unigene: 184926 Human Unigene: 1337 Mouse 趨化因子是當(dāng)今細(xì)胞因子研究領(lǐng)域的熱點(diǎn)之一,它參與多種免疫及炎癥反應(yīng),在感染、腫瘤的生長(zhǎng)與轉(zhuǎn)移、組織修復(fù)及創(chuàng)傷愈合等病理生理過(guò)程中發(fā)揮重要作用. C-C型趨化因子受體4(CCR4)在Th2細(xì)胞表面有大量表達(dá).CCR4在腫瘤的生長(zhǎng)與轉(zhuǎn)移方面起到一定的作用。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Bone (Mouse) Lysate at 40 ug
Lane 2: Bone (Rat) Lysate at 40 ug
Primary: Anti-CCR4 (bs-20788R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 42 kD
Observed band size: 42 kD
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