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Rabbit Anti-N4BP2L2/PFAAP5  antibody (bs-18986R)  
~~~促銷代碼KT202411~~~
訂購(gòu)熱線:400-901-9800
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說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-18986R
英文名稱 Rabbit Anti-N4BP2L2/PFAAP5  antibody
中文名稱 泛素連接酶NEDD4結(jié)合蛋白2樣蛋白2抗體
別    名 92M18.3 (novel protein); 92M18.3; CG005; CG016; FLJ36195; FLJ41089; FLJ43077; N4BP2L2; NEDD4 binding protein 2 like 2; PFAAP5; Phosphonoformate immuno associated protein 5; Protein from BCRA2 region.  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞分化  表觀遺傳學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 67kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞外基質(zhì) 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human N4BP2L2/PFAAP5: 451-550/583 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 PFAAP5 is a 583 amino acid nuclear protein that potentially is involved in transcriptional regulation. PFAAP5 is phosphorylated on Ser 199 in response to DNA damage, probably by ATM or ATR. Primarily expressed in bone marrow, PFAAP5 is dramatically down-regulated after exposure to arsenic compounds, an event which precedes neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, two proteins that are implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase, ELA2, are the cause of cyclic haematopoiesis, which, with decreased numbers of circulating neutrophils, leads to an increased risk for opportunistic infection. Gfi1 is a transcriptional repressor that targets the ELA2 gene among others. With PFAAP5 expression, Neutrophil Elastase can potentiate repression of Gfi1 target genes, leading to the transcription of ELA2 and subsequent neutrophil differentiation. There are two isoforms of PFAAP5 that are produced as a result of alternative splicing events.

SWISS:
Q92802

Gene ID:
10443

Database links:

Entrez Gene: 10443 Human

Entrez Gene: 381695 Mouse

SwissProt: Q92802 Human

SwissProt: Q8JZS6 Mouse



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