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ZFP161 Rabbit pAb (bs-18527R)  
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50ul/1180.00元
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產(chǎn)品編號(hào) bs-18527R
英文名稱 ZFP161 Rabbit pAb
中文名稱 鋅指蛋白161抗體
別    名 HZF5; MGC126126; ZBTB14; ZF161_HUMAN; ZF5; Zfp 161; Zfp-161; Zfp-5; Zfp161; Zinc finger and BTB domain containing protein 14; Zinc finger and BTB domain-containing protein 14; Zinc finger protein 161 homolog(mouse); Zinc finger protein 161 homolog; Zinc f  
研究領(lǐng)域 神經(jīng)生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat (predicted: Human,Mouse,Rabbit,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 51 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZFP161: 181-280/449 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 ZFP161 is a 449 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to distinct regions within the nucleus, ZFP161 functions both as a transcriptional repressor of Thymidine Kinase (TK) and c-Myc promoters and as a transcriptional activator of the dopamine transporter (DAT) promoter. ZFP161 contains one BTB (POZ) domain and five C2H2-type zinc fingers which direct its specific localization and nucleic acid binding, respectively. Defects in the gene encoding ZFP161 may be associated with holoprosencephaly type 4 (HPE4), a structural anomaly of the brain characterized by a flattened nasal tip with no visible septum, hypotelorism, lack of nasal bridge, ptosis of the left upper eyelid and, in some cases, infant death.

Function:
Transcriptional repressor of MYC and thymidine kinase promoters (By similarity). Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 1 BTB (POZ) domain.
Contains 5 C2H2-type zinc fingers.

SWISS:
O43829

Gene ID:
7541

Database links:

Entrez Gene: 7541 Human

Entrez Gene: 22666 Mouse

Entrez Gene: 282825 Rat

Omim: 602126 Human

SwissProt: O43829 Human

SwissProt: Q08376 Mouse

Unigene: 592340 Human



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (Rat ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ZFP161) Polyclonal Antibody, Unconjugated (bs-18527R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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