| 產(chǎn)品編號(hào) | bs-13521R |
| 英文名稱 | Rabbit Anti-GPR17 antibody |
| 中文名稱 | G蛋白偶聯(lián)受體17抗體 |
| 別 名 | DKFZp686M18273; G protein coupled receptor 17; G-protein coupled receptor 17; GPR 17; Gpr17; GPR17_HUMAN; P2Y like receptor; P2Y-like receptor; Probable P2Y purinoceptor GPR 17; Probable P2Y purinoceptor GPR17; R12; UDP/CysLT receptor; Uracil nucleotide/cysteinyl leukotriene receptor; GPCR GPR17. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 41kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human G protein coupled receptor 17: 2-100/367 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
G protein-coupled receptor 17, GPR17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family of proteins. While GPR17 is expressed in kidney, heart and umbilical vein endothelial cells, it is expressed in the highest levels in the brain. Upon brain injury, the extracellular concentrations of nucleotides and cysteinyl leukotrienes (CysLTs), two families of endogenous signaling molecules, increase significantly at the site of damage. In some neurons, GPR17, a membrane receptor for uracil nucleotide and CysLTs, is upregulated as well, infiltrating the lesioned area. GPR17 is thought to play a role in mediating neuronal death, remodeling brain circuitries by microglia and initiating remyelination in damaged neurons. Two named isoforms of GPR17 exist as a result of alternative splicing events. Function: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. Subcellular Location: Cell membrane. Tissue Specificity: Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q13304 Gene ID: 2840 Database links: Entrez Gene: 2840 Human Entrez Gene: 574402 Mouse Omim: 603071 Human SwissProt: Q13304 Human SwissProt: Q6NS65 Mouse Unigene: 46453 Human Unigene: 688940 Human Unigene: 391108 Mouse Unigene: 212749 Rat |
