| 產(chǎn)品編號(hào) | bs-8609R |
| 英文名稱 | Rabbit Anti-LGR6 antibody |
| 中文名稱 | G蛋白偶聯(lián)受體6抗體 |
| 別 名 | GPCR LGR6; FLJ14471; Gonadotropin receptor; GPCR; Leucine-rich repeat-containing G protein-coupled receptor 6; Leucine-rich repeat-containing G-protein coupled receptor 6; Lgr6; LGR6_HUMAN; VTS20631. |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 104kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LGR6: 401-500/967 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors and heptahelical receptors, are a protein family which interact with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers such as diacylglycerol, cyclic AMP, inositol phosphates and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. The GPCR family represents the largest class of targets for modern drugs. Leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6) is an orphan-A GPCR with an N-terminal ectodomain comprising variable leucine-rich repeats, a 7TM region and a unique C-terminal intracellular tail. The sequence of LGR6 is similar to TSHR, FSHR and LHR. LGR6 is predominantly expres-sed in the adrenal gland, ovary and uterus. Function: Orphan receptor. Subcellular Location: Cell membrane. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the G-protein coupled receptor 1 family. Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. SWISS: Q9HBX8 Gene ID: 59352 Database links: Entrez Gene: 59352 Human Entrez Gene: 329252 Mouse Omim: 606653 Human SwissProt: Q9HBX8 Human SwissProt: Q3UVD5 Mouse Unigene: 497402 Human Unigene: 279594 Mouse |
