| 產(chǎn)品編號(hào) | bs-4150R |
| 英文名稱 | Rabbit Anti-Kv2.1 antibody |
| 中文名稱 | 鉀通道蛋白DRK1抗體 |
| 別 名 | Delayed rectifier potassium channel 1; Delayed rectifier potassium channel Kv2.1; DRK 1; DRK1; h DRK1 K(+) channel; h-DRK1; hDRK 1; hDRK1; KCB 1; KCB1; KCNB1; KCNB1_HUMAN; KV2.1; Potassium channel protein DRK1; Potassium voltage gated channel shab related subfamily member 1; Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel subunit Kv2.1. |
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Specific References (1) | bs-4150R has been referenced in 1 publications.
[IF=3.8] Pucca, Manuela Berto, et al. "Immunosuppressive evidence of Tityus serrulatus toxins Ts6 and Ts15: insights of a novel K+ channel pattern in T cells." Immunology (2015). Mouse.
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| 研究領(lǐng)域 | 免疫學(xué) 細(xì)胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 96kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DRK1: 465-570/858 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Subunit: Heteromultimer with KCNG2, KCNG3, KCNG4, KCNS1, KCNS2, KCNS3 and KCNV2 (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein. Post-translational modifications: Highly phosphorylated on serine residues in the C-terminal. Differential phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are all regulated by calcineurin-mediated dephosphorylation. Particularly, Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/ dephosphorylation activities. Tyr-128 can be dephosphorylated by PTPalpha and cyt-PTPepsilon. Phosphorylation levels on Ser-607 are supersensitive to neuronal activity. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5. Levels then increase to reach adult levels by P14. Phosphorylation levels on Ser-564 and Ser-607 are greatly reduced during seizures, by 40% and 85% respectively (By similarity). Similarity: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily. SWISS: Q14721 Gene ID: 3745 Database links: Entrez Gene: 3745 Human Entrez Gene: 16500 Mouse Omim: 600397 Human SwissProt: Q14721 Human SwissProt: Q03717 Mouse Unigene: 84244 Human Unigene: 387390 Mouse Unigene: 26724 Rat |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with Kv2.1 polyclonal antibody, unconjugated (bs-4150R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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