| 產(chǎn)品編號 | bs-3638R |
| 英文名稱 | Rabbit Anti-Plexin A2 antibody |
| 中文名稱 | 神經(jīng)叢蛋白A2抗體 |
| 別 名 | PlexinA2; PLXA2; PLXNA2; Semaphorin receptor OCT. |
| 研究領(lǐng)域 | 免疫學(xué) 神經(jīng)生物學(xué) 細(xì)胞膜受體 細(xì)胞表面分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 205kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Plexin A2: 1251-1400/1894 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Plexin A2 is a coreceptor for SEMA3A and is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. This coreceptor plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin in which the plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Function: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). Subunit: Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2 (By similarity). Interacts with RND1. Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Tissue Specificity: Detected in fetal brain. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain. SWISS: O75051 Gene ID: 5362 Database links: Entrez Gene: 5362 Human Entrez Gene: 18845 Mouse Omim: 601054 Human SwissProt: O75051 Human SwissProt: P70207 Mouse Unigene: 497626 Human Unigene: 2251 Mouse Plexin A2蛋白是SEMA3A的輔助受體，Plexin A2蛋白在神經(jīng)細(xì)胞軸突導(dǎo)向, 生長和細(xì)胞遷移中發(fā)揮作用。 |
