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CD72 Rabbit pAb (bs-2517R)  
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產(chǎn)品編號(hào) bs-2517R
英文名稱 CD72 Rabbit pAb
中文名稱 CD72蛋白抗體
別    名 B-cell differentiation antigen CD72; CD72b; B cell differentiation antigen CD72; CD72 antigen; CD72 molecule; CD72c; Ly-19; Ly-32; Ly-m19; Lyb-2; Lyb2; LYB2, mouse, homolog of; Lymphocyte antigen 32; MGC108873; CD72_HUMAN.  
研究領(lǐng)域 腫瘤  免疫學(xué)  干細(xì)胞  細(xì)胞表面分子  糖蛋白  b-淋巴細(xì)胞  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat,Cow,Dog)
產(chǎn)品應(yīng)用 Flow-Cyt=1μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 40 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD72: 4-110/359 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 CD72 antigen is a member of the type II integral membrane glycoproteins which includes other related cell surface molecules such as the asialoglycoprotein receptors, CD23 and the Kupffer cell receptor. The function of CD72 is unknown but the exposure of B cells to CD72 antibodies activates a variety of signaling pathways and can induce MHC class II expression and B cell proliferation. CD72 antigen is expressed on all cells of B cell lineage with the exception of plasma cells and weakly on human tissue macrophages.

Function:
Plays a role in B-cell proliferation and differentiation.

Subunit:
Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).

Subcellular Location:
Membrane; Single-pass type II membrane protein.

Tissue Specificity:
Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Post-translational modifications:
Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).

Similarity:
Contains 1 C-type lectin domain.

SWISS:
P21854

Gene ID:
971

Database links:

Entrez Gene: 971 Human

Omim: 107272 Human

SwissProt: P21854 Human

Unigene: 116481 Human



CD72是一個(gè)重要的B細(xì)胞特異性受體。屬于II型膜內(nèi)糖蛋白成員中的細(xì)胞表面分子非唾液酸糖蛋白受體,雖然其分子功能目前還不清楚,但目前發(fā)現(xiàn)CD72的多態(tài)性與多種腫瘤有關(guān)。
產(chǎn)品圖片
Blank control(blue):Raji cells (fixed with 2% paraformaldehyde (10 min)) . Primary Antibody:Rabbit Anti- CD72 antibody(bs-2517R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same cond
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