| 產(chǎn)品編號(hào) | bs-1894R |
| 英文名稱(chēng) | Rabbit Anti-GRM4 antibody |
| 中文名稱(chēng) | 促代謝型谷氨酸受體4抗體 |
| 別 名 | G protein coupled receptor family C group 1 member D; G protein coupled receptor GRM 4; G protein coupled receptor GRM4; Glutamate receptor metabotropic 4; GPRC 1D; GPRC1D; GRM 4; GRM4; GRM4_HUMAN; Metabotropic glutamate receptor 4; mGlu 4; mGlu R4; mGlu4; mGluR 4; mGluR4. |
| 研究領(lǐng)域 | 免疫學(xué) 神經(jīng)生物學(xué) 細(xì)胞凋亡 G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Rabbit,Pig) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 102kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GRM4: 301-400/912 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Subunit: Interacts with PICK1 Subcellular Location: Cell membrane. Tissue Specificity: Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver. Similarity: Belongs to the G-protein coupled receptor 3 family. SWISS: Q14833 Gene ID: 2914 Database links: Entrez Gene: 2914 Human Entrez Gene: 268934 Mouse Omim: 604100 Human SwissProt: Q14833 Human SwissProt: Q68EF4 Mouse Unigene: 429018 Human |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with GRM4 polyclonal antibody, unconjugated (bs-1894R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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