| 產(chǎn)品編號 | bs-2083R |
| 英文名稱 | Rabbit Anti-DcR1 antibody |
| 中文名稱 | 腫瘤壞死因子配體超家族成員10C |
| 別 名 | Decoy receptor 1;TNFRSF10C; CD263; DcR 1; LIT; Lymphocyte inhibitor of TRAIL; TNF Related Apoptosis Inducing Ligand Receptor 3; TNFRSF10C; TRAIL R3; TRAIL receptor 3; TRAIL Receptor Without An Intracellular Domain; TRAILR3; TRID; Tumor Necrosis Factor Receptor Superfamily Member 10C; DcR1; TRAIL-R3. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 細(xì)胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 23kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TNFRSF10C: 51-150/259 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]. Function: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart. Post-translational modifications: N-glycosylated and O-glycosylated. Similarity: Contains 3 TNFR-Cys repeats. SWISS: O14798 Gene ID: 8794 Database links: Entrez Gene: 8794 Human Omim: 603613 Human SwissProt: O14798 Human DcR1因缺乏細(xì)胞內(nèi)信號傳導(dǎo)系統(tǒng)而不能傳遞凋亡信號,但能競爭性與TRAIL（腫瘤壞死因子相關(guān)凋亡誘導(dǎo)配體）結(jié)合,有干擾凋亡信號的傳導(dǎo)作用。 |
