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Rabbit Anti-Caveolin-1  antibody (bs-1453R)  
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產(chǎn)品編號 bs-1453R
英文名稱 Rabbit Anti-Caveolin-1  antibody
中文名稱 細胞質(zhì)膜微囊蛋白-1抗體
別    名 opamine D3 receptor; Caveolin1; Caveolin 1; 3 dopamine receptor; D; Dopamine receptor D3; DRD; ETM1; FET1; Cav-1; ETM1; CAV 1; CAV1; CAV1_HUMAN.  
Specific References  (9)     |     bs-1453R has been referenced in 9 publications.
[IF=8] Dixit, Saurabh, et al. "Caveolin-mediated endocytosis of the Chlamydia M278 outer membrane peptide encapsulated in poly (lactic acid)-Poly (ethylene glycol) nanoparticles by mouse primary dendritic cells enhances specific immune effectors mediated by MHC class II and CD4+ T cells." Biomaterials (2017).  IF(ICC) ;  Mouse.  
[IF=6.205] Cheng S et al. Comparative analysis of Longissimus dorsi tissue from two sheep groups identifies differentially expressed genes related to growth, development and meat quality. Genomics. 2020 Sep;112(5):3322-3330.  WB ;  Sheep.  
[IF=5.818] Yingna Huang. et al. Nisoldipine Inhibits Influenza A Virus Infection by Interfering with Virus Internalization Process. VIRUSES-BASEL. 2022 Dec;14(12):2738  WB ;  Human.  
[IF=5.17] Zhang et al. P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis. (2015) Oncotarge. 6:789-801  WB, IF(ICC) ;  Human.  
[IF=4.831] Zhang Q et al. CTRP13 attenuates the expression of LN and CAV-1 Induced by high glucose via CaMKKβ/AMPK pathway in rLSECs. Aging (Albany NY). 2020 Jun 17;12(12):11485-11499.  WB ;  Rat.  
[IF=4.486] Xian J et al. Progress in the research of p53 tumour suppressor activity controlled by Numb in triple‐negative breast cancer. J Cell Mol Med. 2020 Jul;24(13):7451-7459.  WB ;  Human.  
[IF=3.471] Quanwei Zhang. et al. DIA proteomics identified the potential targets associated with angiogenesis in the mammary glands of dairy cows with hemorrhagic mastitis. FRONT VET SCI. 2022; 9: 980963  IHC, IF ;  Bovine.  
[IF=3.297] Hao Chen. et al. MicroRNA-124-3p affects myogenic differentiation of adipose-derived stem cells by targeting Caveolin-1 during pelvic floor dysfunction in Sprague Dawley rats. Ann Transl Med. 2021 Jan; 9(2): 161  WB ;  Rat.  
[IF=1.79] Cheng, Mao-Feng, et al. "The role of rosiglitazone in the proliferation of vascular smooth muscle cells after experimental subarachnoid hemorrhage." Acta Neurochirurgica (2014): 1-7.  IHC-P ;  Rat.  
研究領(lǐng)域 信號轉(zhuǎn)導(dǎo)  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat (predicted: Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 20kDa
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Caveolin-1: 2-120/178 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [provided by RefSeq].

Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

Subunit:
Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK.

Subcellular Location:
Golgi apparatus membrane;Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.

Tissue Specificity:
Expressed in muscle and lung, less so in liver, brain and kidney.

Post-translational modifications:
The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.
Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.

DISEASE:
Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.

Similarity:
Belongs to the caveolin family.

SWISS:
Q03135

Gene ID:
857

Database links:

Entrez Gene: 403980 Dog

Entrez Gene: 857 Human

Entrez Gene: 12389 Mouse

Entrez Gene: 25404 Rat

Omim: 601047 Human

SwissProt: P33724 Dog

SwissProt: Q03135 Human

SwissProt: P49817 Mouse

SwissProt: P41350 Rat

Unigene: 3850 Dog

Unigene: 74034 Human

Unigene: 28278 Mouse

Unigene: 470537 Mouse

Unigene: 22518 Rat



信號傳導(dǎo)(Signaling Intermediates)
Caveolin-1(小凹蛋白)是細胞生長相關(guān)信號途徑及腫瘤發(fā)生發(fā)展過程中重要的抑制因子,Caveolae是細胞膜內(nèi)的特殊膜結(jié)構(gòu),參與包括細胞的分子運輸、細胞粘附和信號轉(zhuǎn)導(dǎo)在內(nèi)的多種細胞活動。Caveolin-1是Caveolae中重要的結(jié)構(gòu)蛋白,抑制細胞生長,與多種人類腫瘤發(fā)生發(fā)展相關(guān)的信號分子相互作用。Caveolin在信號轉(zhuǎn)導(dǎo)的整合中起支架蛋白的作用。Caveolin構(gòu)成了一個蛋白家族,他們是細胞質(zhì)膜中發(fā)夾樣結(jié)構(gòu)域的主要結(jié)構(gòu)成分。Caveolin在信號轉(zhuǎn)導(dǎo)的整合中起支架蛋白的作用。至今已經(jīng)鑒定了3種Caveolin (Caveolin-1、2 和3),它們具有不同的組織分布。Caveolin-1涉及乳腺上皮細胞增生的發(fā)病機制。該抗體可識別α和β型Caveolin-1。
產(chǎn)品圖片
Sample: Lung (Mouse) Lysate at 40 ug Bladder (Mouse) Lysate at 40 ug Primary: Anti-Caveolin-1 (bs-1453R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 20 kD Observed band size: 20 kD
Sample: Lung (Mouse) Lysate at 40 ug Primary: Anti-Caveolin-1 (bs-1453R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 20 kD Observed band size: 20 kD
Sample: NIH/3T3 Cell Lysate at 40 ug A549 Cell Lysate at 40 ug HUVEC Cell Lysate at 40 ug Primary: Anti-Caveolin-1 (bs-1453R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 20 kD Observed band size: 20 kD
Tissue/cell: mouse retina tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Caveolin-1 Polyclonal Antibody, Unconjugated(bs-1453R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Caveolin-1 Polyclonal Antibody, Unconjugated(bs-1453R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Paraformaldehyde-fixed, paraffin embedded (Rat ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Caveolin-1) Polyclonal Antibody, Unconjugated (bs-1453R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining.
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