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Integrin alpha 5 Rabbit pAb (bs-0567R)  
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產(chǎn)品編號 bs-0567R
英文名稱 Integrin alpha 5 Rabbit pAb
中文名稱 整合素α5(CD49e)抗體
別    名 alpha 5 beta 1; CD49 antigen-like family member E; CD49e; ECMRVI; Fibronectin Receptor alpha; Fibronectin receptor alpha subunit; Fibronectin receptor, alpha subunit; FNR; FNRA; gpIc/IIa; Integrin alpha 5(fibronectin receptor alpha); Integrin alpha F; Int  
Specific References  (7)     |     bs-0567R has been referenced in 7 publications.
[IF=3.848] Song Danyang. et al. Silencing of ER-resident oxidoreductase PDIA3 inhibits malignant biological behaviors of multidrug-resistant gastric cancer. Acta Bioch Bioph Sin. 2021 Aug;:  IHC ;  Human.  
[IF=3.565] Tao Wang. et al. Preliminary study on SPECT/CT imaging of pancreatic cancer xenografts by targeting integrin α5 in pancreatic stellate cells. J Cancer. 2021; 12(6): 1729–1733  WB,IHC ;  Human.  
[IF=2.93] Cui, Li, et al. "The Role of Integrin-α5 in the Proliferation and Odontogenic Differentiation of Human Dental Pulp Stem Cells." Journal of endodontics 40.2 (2014): 235-240.  WB ;  Human.  
[IF=2.813] Lu, Kang. et al. N-Acetyl-L-cysteine facilitates tendon repair and promotes the tenogenic differentiation of tendon stem/progenitor cells by enhancing the integrin α5/β1/PI3K/AKT signaling. BMC MOL CELL BIOL. 2023 Dec;24(1):1-13  WB,IF ;  Rat.  
[IF=2.81] Torkamani, N., et al. "Epidermal Cells Expressing Putative Cell Markers in Nonglabrous Skin Existing in Direct Proximity with the Distal End of the Arrector Pili Muscle." Stem Cells International 2016 (2016).  IHC-F ;  Mouse.  
[IF=2.81] Zhang, Rui, et al. "Rho/MRTF-A-Induced Integrin Expression Regulates Angiogenesis in Differentiated Multipotent Mesenchymal Stem Cells." Stem Cells International 2015 (2015).  WB ;  Rat.  
[IF=2.741] Cui, Xiyao. et al. TMT-based proteomic analysis reveals integrins involved in the synergistic infection of reticuloendotheliosis virus and avian leukosis virus subgroup J. BMC VET RES. Bmc Vet Res. 2022 Dec;18(1):1-8  WB ;  Chicken.  
研究領(lǐng)域 細胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  干細胞  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat,Rabbit,Pig,Sheep,Cow,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 110 kDa
檢測分子量 135
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Integrin alpha-5 light chain: 1021-1099/1099 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

Function:
CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling.

Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV-1 Tat.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.

SWISS:
P08648

Gene ID:
3678

Database links:

Entrez Gene: 3678 Human

Entrez Gene: 16402 Mouse

Entrez Gene: 315346 Rat

Omim: 135620 Human

SwissProt: P08648 Human

SwissProt: P11688 Mouse

Unigene: 505654 Human

Unigene: 16234 Mouse

Unigene: 100796 Rat



ITG-α5粘附分子整合素α5也是細胞粘附分子的超家族成員,廣泛分布于細胞表面和細胞外基質(zhì)的糖蛋白,不僅介導(dǎo)細胞與細胞或細胞與基質(zhì)之間的連接,而且參與細胞間的信號轉(zhuǎn)導(dǎo),細胞的生長移行,腫瘤的轉(zhuǎn)移浸潤,免疫炎性反應(yīng),血管生成等一系列的生理和病理過程。
產(chǎn)品圖片
Sample: Lane 1: NIH/3T3 (Mouse) Cell Lysate at 30 ug Lane 2: A549 (Human) Cell Lysate at 30 ug Lane 3: U87MG (Human) Cell Lysate at 30 ug Lane 4: K562 (Human) Cell Lysate at 30 ug Lane 5: Huvec (Human) Cell Lysate at 30 ug Primary: Anti-Integrin alpha 5 (bs-0567R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 140 kD Observed band size: 140 kD
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