| 產(chǎn)品編號 | bs-0652R |
| 英文名稱 | Connexin-45 Rabbit pAb |
| 中文名稱 | 間隙連接蛋白45抗體 |
| 別 名 | Connexin 45; Connexin45; Connexin-45; CX 31.9; CX 45; CX31.9; CX45; DKFZp686P0738; Gap junction alpha 7 protein; Gap junction alpha-7 protein; Gap junction protein alpha 7 45kDa; Gap junction protein alpha 7; Gap junction protein, gamma 1, 45kDa; GJA 7; GJA7; GJD3; Gap junction gamma-1 protein; CXG1_HUMAN. |
| 研究領(lǐng)域 | 心血管 信號轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Pig,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 45 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Connexin-45: 81-130/396 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Subunit: A connexon is composed of a hexamer of connexins. Interacts with CNST. Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Similarity: Belongs to the connexin family. Gamma-type subfamily. SWISS: P36383 Gene ID: 10052 Database links: Entrez Gene: 10052 Human Entrez Gene: 14615 Mouse Omim: 608655 Human SwissProt: P36383 Human SwissProt: P28229 Mouse Unigene: 195419 Rat 通道蛋白（Channel Protein） Connexin45又稱縫隙連接膜通道蛋白alpha7，Cx45構(gòu)成細(xì)胞間的通道,小分子成份可以借此在細(xì)胞間擴(kuò)散。 Connexin-45是心肌縫隙連接蛋白的主要蛋白之一。 |
