mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
成人毛片女人毛片免费96,欧美亚洲另类日韩综合网,午夜精品日韩在线播放
Rabbit Anti-GATA4 /BF555 Conjugated antibody (bs-23983R-BF555)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@m.p2b3.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@m.p2b3.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-23983R-BF555
英文名稱 Rabbit Anti-GATA4 /BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的GATA結(jié)合蛋白4抗體
別    名 GATA binding factor 4; GATA 4; GATA4; GATA-4; Transcription factor GATA-4; GATA-binding factor 4; Gata4; GATA4_HUMAN; GATA-binding factor 4.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  發(fā)育生物學(xué)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GATA4
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
GATA4 is a 46 kDa member of the GATA family of zinc finger containing transcription factors that is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs.

Function:
Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement.

Subunit:
Interacts with ZNF260. Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes.

Subcellular Location:
Nucleus.

Post-translational modifications:
Methylation at Lys-300 attenuates transcriptional activity.

DISEASE:
Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.

Similarity:
Contains 2 GATA-type zinc fingers.

Database links:

Entrez Gene: 2626 Human

Entrez Gene: 14463 Mouse

Entrez Gene: 54254 Rat

Omim: 600576 Human

SwissProt: P43694 Human

SwissProt: Q08369 Mouse

SwissProt: P46152 Rat

Unigene: 243987 Human

Unigene: 247669 Mouse

Unigene: 26251 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GATA-4屬于轉(zhuǎn)錄調(diào)節(jié)性因子,表達(dá)在心組織、胃腸道組織中,并調(diào)節(jié)該類T細(xì)胞的發(fā)育和功能。
版權(quán)所有 2004-2026 www.m.p2b3.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
三级成人国产高清视频| 日韩av午夜福利在线观看| 男生操女生无马赛克免费| 久久久国产调教性奴| 中文字幕乱码人妻一区二区三区| 白嫩在线亚洲观看| 日本欧美中文字幕| 日日爱黄色毛片视频| 黄色av成年人在线观看| 在线免费观看一区二区三区| 日韩亚洲AV无码一区二区不卡| 性一交一子一伦一乱| 性一乱一交一免费看视频| 猛哥操女人B视频| 午夜性无码视频在线播放| 欧美日韩一级视频| 波多野吉衣一区在线观看| 国产天美传媒剧免费观看| 精品一区二区三区成人免费视频| 操逼操的翻白眼视频| 中文字幕欧美中日韩精品| 国产乱理伦片在线观看夜| 泰国无码AV片在线观看| 欧美一级特黄大片在线看| 中文字幕一区二区日韩精品蜜臂| 日韩人妻精品一区二区三区| 中文字幕在线精品的视频| 成人国产亚洲精品一区二| 男人大鸡巴操小鲜肉视频| 喜欢被粗大阴茎插入| 大狼狗插阴道视频| 91精品欧美久久久久久| 性一乱一交一免费看视频| 精品v欧洲高清欧美| 亚洲女同一区二区三久久精品| 色逼色逼色逼色逼色逼色| 大鸡巴抽插小骚逼视频免费| 人人超级碰青青精品| 操大屌粉的小穴视频| 大屌把女生逼逼操肿国产| 麻豆视频一级片在线观看|