| 產(chǎn)品編號(hào) | bsm-33075M-Bio |
| 英文名稱(chēng)1 | Mouse Anti-CD2/Biotin Conjugated antibody |
| 中文名稱(chēng) | 生物素標(biāo)記的CD2單克隆抗體 |
| 別 名 | T-cell surface antigen CD2; CD 2; CD2 antigen; CD2 molecule; LFA2; LFA3 receptor; Lymphocyte function antigen 2; p50; Rosette receptor; Sheep erythrocyte receptor; Sheep red blood cell receptor; SRBC; T cell surface antigen CD2; T cell surface antigen T11/Leu 5; T11; CD2_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 免疫學(xué) 細(xì)胞表面分子 t-淋巴細(xì)胞 |
| 抗體來(lái)源 | Mouse |
| 克隆類(lèi)型 | Monoclonal |
| 克 隆 號(hào) | 5H3 |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein G |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin. Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. Subunit: Interacts with CD2AP. Interacts with PSTPIP1. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 914 Human Entrez Gene: 12481 Mouse Omim: 186990 Human SwissProt: P06729 Human SwissProt: P08920 Mouse Unigene: 523500 Human Unigene: 22842 Mouse Unigene: 10328 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD2分子又稱(chēng)T11、綿羊紅細(xì)胞受體（ER）、淋巴細(xì)胞功能相關(guān)抗原2（LFA-2）和Leu5，是人T淋巴細(xì)胞表面的單鏈糖蛋白.CD2分子是分布于胸腺細(xì)胞及所有成熟T淋巴細(xì)胞和大部分自然殺傷細(xì)胞表面的特征性分化抗原。CD2具有調(diào)節(jié)T淋巴細(xì)胞分化、成熟、激活和凋亡等功能，CD2與LFA-3之間的粘附功能對(duì)于T淋巴細(xì)胞TCR識(shí)別外來(lái)抗原與APC細(xì)胞表面MHC抗原復(fù)合物、腫瘤抗原、病毒感染靶細(xì)胞以及同種異體抗原均有重要的輔助作用。 最近研究表明，CD48和CD59也是CD2的配體，參與T細(xì)胞的粘附和細(xì)胞間的相互作用,此外，CD2可以與其它膜分子如CD44、CD45的功能有關(guān)。CD2具有對(duì)T細(xì)胞的旁路激活途徑作用。 |
