mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲欧美国产日韩中文,18禁的黄色av网站在线浏览,国产成人精品综合在线
Mouse Anti-XRCC4/PE-Cy5 Conjugated antibody (bsm-33092M-PE-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@m.p2b3.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@m.p2b3.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bsm-33092M-PE-Cy5
英文名稱 Mouse Anti-XRCC4/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的DNA修復(fù)基因XRCC4單克隆抗體
別    名 X-Ray Repair Cross Complementing 4; X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 4; XRCC4_HUMAN; DNA Repair Protein XRCC4; X-Ray Repair, Complementing Defective, Repair In Chinese Hamster; X-Ray Repair Cross-Complementing Protein 4; SSMED;   
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號(hào)  
抗體來(lái)源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) 7D11
交叉反應(yīng)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human XRCC4
亞    型 IgG
純化方法 affinity purified by Protein G
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015]

Function:
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Subunit:
Homodimer and homotetramer in solution. The homodimer associates with LIG4. The LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex composed of PRKDC, XRCC6/Ku70 and XRCC5/Ku86 to form the core non-homologous end joining (NHEJ) complex. Additional components of the NHEJ complex include NHEJ1/XLF and C9orf142/PAXX. Interacts directly with PRKDC but not with the XRCC6/Ku70 and XRCC5/Ku86 dimer. Interacts with APTX and APLF.

Subcellular Location:
Nucleus

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Phosphorylated by PRKDC. The phosphorylation seems not to be necessary for binding to DNA.
Phosphorylation by CK2 promotes interaction with APTX.
Monoubiquitinated.
Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. Has no effect on ubiquitination.


DISEASE:
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by short stature and microcephaly apparent at birth, progressive post-natal growth failure, and endocrine dysfunction. In affected adults endocrine features include hypergonadotropic hypogonadism, multinodular goiter, and diabetes mellitus. Variable features observed in some patients are progressive ataxia, and lymphopenia or borderline leukopenia.

Similarity:
Belongs to the XRCC4 family.

Database links:

Entrez Gene: 7518 Human

Omim: 194363 Human

SwissProt: Q13426 Human

Unigene: 567359 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.m.p2b3.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
综合伊人久久在一二三区| 91久久高清国语自产拍| 快日我啊好爽日我逼| 鸡巴插进缝里 日本| 我想看操小嫩逼大片| 日韩精品无码一区二区三区不卡| 日本不卡免费一区二区视频| 日韩美女叉B视频| 国产精品操大屁股老淑女| 亚洲精品自拍偷拍| 亚洲福利左线观看| 啊啊啊男女激情插插视频| 韩国无遮挡成人免费视频| 丁香婷婷色婷婷粗大| 国产区高清在线一区二区三区| 尤物网三级在线观看| 又大黄又硬又爽免费视频| 男人透女人视频短篇| 国产精品国产三级国| 亚洲精品成人无码app| 日韩精品无码一区二区三区不卡| 欧美性一区二区三区五区| 国产三级精品久久久久| 欧美精品性做久久久久久| 国产精品三二一免费| 粉嫩小穴被大鸡巴操视频在线观看| 一级特黄大片色欧美精品| 美女麻豆颜色光屁股眼子| 99精品一级欧美片免费| 韩国三级a视频哪里看| 多男用舌头伺候一女| 亚洲精品自拍偷拍第一页| 色噜噜在线一区二区三区| 美国业余自由摘花管| 人人超级碰青青精品| 久久久国产了楼凤| 欧美日韩亚洲人人夜夜澡| 男的日女生批网页| 美女张开腿让男人桶91| 国产精品高潮久久久久a| 欧美一区二区三区久久国产精品|