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Rabbit Anti-ZNF238/APC Conjugated antibody (bs-7195R-APC)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-7195R-APC
英文名稱1 Rabbit Anti-ZNF238/APC Conjugated antibody
中文名稱 APC標(biāo)記的鋅指蛋白238抗體
別    名 58 kDa repressor protein; C2H2 171; C2H2171; RP58; TAZ 1; TAZ-1; TAZ1; Transcriptional repressor RP58; Translin associated zinc finger protein 1; Translin-associated zinc finger protein 1; ZBTB18; Zinc finger and BTB domain containing protein 18; Zinc finger and BTB domain-containing protein 18; Zinc finger protein 238; Zinc finger protein C2H2 171; Zinc finger protein C2H2-171; ZN238_HUMAN; ZNF238.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 轉(zhuǎn)錄調(diào)節(jié)因子  結(jié)合蛋白  鋅指蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Chicken, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 58kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZNF238
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Function:
Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons (By similarity). Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.

Subcellular Location:
Nucleus. Associates with condensed chromatin.

Tissue Specificity:
Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 BTB (POZ) domain.
Contains 4 C2H2-type zinc fingers.

Database links:

Entrez Gene: 10472 Human

Entrez Gene: 30928 Mouse

Entrez Gene: 64619 Rat

Omim: 608433 Human

SwissProt: Q99592 Human

SwissProt: Q9WUK6 Mouse

SwissProt: Q9JKY3 Rat

Unigene: 69997 Human

Unigene: 207206 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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