| 產(chǎn)品編號(hào) | bs-17111R-BF488 |
| 英文名稱 | Rabbit Anti-LAX1/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的膜相關(guān)接頭蛋白LAX抗體 |
| 別 名 | FLJ20340; LAT like membrane associated protein; LAX; LAX1_HUMAN; Linker for activation of X cells; Lymphocyte transmembrane adaptor 1; Membrane associated adapter protein LAX; OTTHUMP00000034094. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 激酶和磷酸酶 淋巴細(xì)胞 t-淋巴細(xì)胞 b-淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LAX1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: LAX1 is a 398 amino acid single-pass type III membrane protein that negatively regulates lymphocyte signaling. LAX1 is expressed in lymphoid tissues including thymus, spleen and peripheral blood leukocytes, along with several B-cell, T-cell, natural killer and monocyte cell lines. When stimulated by B or T cells, LAX1 becomes dramatically upregulated and also interacts with GRB2, Gads and PI 3-kinase p85 upon phosphorylation. LAX1 exists as two alternatively spliced isoforms that are encoded by a gene located on human chromosome 1. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Function: LAX1 negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. Subunit: When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2. Subcellular Location: Cell Membrane; Single-pass type III membrane protein. Tissue Specificity: Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines. Post-translational modifications: Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2. Database links: Entrez Gene: 54900 Human SwissProt: Q8IWV1 Human Unigene: 272794 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
