| 產(chǎn)品編號(hào) | bs-16694R-APC |
| 英文名稱1 | Rabbit Anti-IRAK1BP1/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的白細(xì)胞介素1受體相關(guān)激酶1結(jié)合蛋白1抗體 |
| 別 名 | ActA binding protein 3; AIP70; IKBP1_HUMAN; Interleukin 1 receptor associated kinase 1 binding protein 1; IRAK1-binding protein 1; Signaling molecule that associates with Pelle-like kinase; SIMPL. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 激酶和磷酸酶 結(jié)合蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IRAK1BP1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: IRAK1BP1 is a component of the IRAK1 dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. It acts by enhancing RELA transcriptional activity. Function: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. similarity). {ECO:0000250}. Subunit: Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1 (By similarity). {ECO:0000250}. Subcellular Location: Cytoplasmic and Nuclear Post-translational modifications: Phosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity). {ECO:0000250}. Similarity: Belongs to the IRAK1BP1 family. {ECO:0000305}. Database links: Entrez Gene: 134728 Human Entrez Gene: 65099 Mouse Omim: 615375 Human SwissProt: Q5VVH5 Human SwissProt: Q9ESJ7 Mouse Unigene: 656212 Human Unigene: 41415 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
