| 產(chǎn)品編號 | bs-14416R-APC |
| 英文名稱 | Rabbit Anti-DPH3/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的DPH3蛋白抗體 |
| 別 名 | CSL-type zinc finger-containing protein 2; Deafness locus putative guanine nucleotide exchange factor interacting protein 1; DelGEF-interacting protein 1; DELGIP; DelGIP1; DESR1; Diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1; DPH3; DPH3 homolog; DPH3 KTI11 homolog; DPH3_HUMAN; DPH3A; KTI11; MGC20197; ZCSL2; Zinc finger CSL domain containing 2; Zinc finger CSL type containing 2. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 細(xì)菌及病毒 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 9.2kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DPH3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009] Function: Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A. Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung. Similarity: Belongs to the DPH3 family. Contains 1 DPH-type zinc finger. Database links: Entrez Gene: 285381 Human Omim: 608959 Human SwissProt: Q96FX2 Human Unigene: 388087 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
