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      Rabbit Anti-GK2/BF647 Conjugated antibody (bs-13366R-BF647)
      訂購熱線:400-901-9800
      訂購郵箱:sales@m.p2b3.cn
      訂購QQ:  400-901-9800
      技術支持:techsupport@m.p2b3.cn
      說 明 書: 100ul  
      100ul/2980.00元
      大包裝/詢價
      產(chǎn)品編號 bs-13366R-BF647
      英文名稱1 Rabbit Anti-GK2/BF647 Conjugated antibody
      中文名稱 BF647標記的甘油激酶2抗體
      別    名 ATP:glycerol 3 phosphotransferase; EC 2.7.1.30; GK 2; GK; GKP2; GKTA; Glycerokinase; Glycerol kinase 2; Glycerol kinase testis specific 2; GLPK2_HUMAN.  
      規(guī)格價格 100ul/2980元 購買        大包裝/詢價
      說 明 書 100ul  
      研究領域 腫瘤  細胞生物  信號轉導  激酶和磷酸酶  新陳代謝  線粒體  
      抗體來源 Rabbit
      克隆類型 Polyclonal
      交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
      產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
      not yet tested in other applications.
      optimal dilutions/concentrations should be determined by the end user.
      分 子 量 61kDa
      性    狀 Lyophilized or Liquid
      濃    度 1mg/ml
      免 疫 原 KLH conjugated synthetic peptide derived from human GK2/Glycerol kinase 2
      亞    型 IgG
      純化方法 affinity purified by Protein A
      儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
      保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
      產(chǎn)品介紹 background:
      GK2 is a 553 amino acid protein that belongs to the FGGY kinase family and is involved in the pathway of glycerol degradation. Localized to the outer membrane of the mitochondrion and expressed at high levels in testis, GK2 functions to catalyze the ATP-dependent conversion of glycerol to glycerol 3-phosphate. Via its catalytic activity, GK2 plays an essential role in the regulation of glycerol uptake and metabolism. The gene encoding GK2 maps to chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

      Function:
      Key enzyme in the regulation of glycerol uptake and metabolism.

      Subcellular Location:
      Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm the majority of the enzyme is bound to mitochondria.

      Similarity:
      Belongs to the FGGY kinase family.

      Database links:

      Entrez Gene: 2712 Human

      Omim: 600148 Human

      SwissProt: Q14410 Human

      Unigene: 98008 Human



      Important Note:
      This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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