mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
亚洲中文有码一区二区,欧美一区二区三区老人
Rabbit Anti-SPG3A/Biotin Conjugated antibody (bs-11759R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@m.p2b3.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@m.p2b3.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11759R-Bio
英文名稱1 Rabbit Anti-SPG3A/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的G蛋白結(jié)合蛋白3抗體
別    名 Atlastin; AD FSP; atl1; ATLA1_HUMAN; Atlastin GTPase 1; Atlastin-1; Atlastin1; Brain specific GTP binding protein; Brain-specific GTP-binding protein; FSP1; GBP-3; GBP3; GTP-binding protein 3; Guanine nucleotide-binding protein 3; Guanylate binding protein 3; hGBP3; HSN1D; Spastic paraplegia 3 protein A; SPG 3A; SPG3; SPG3A.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  結(jié)合蛋白  G蛋白偶聯(lián)受體  G蛋白信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Rabbit, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPG3A/Atlastin (201-300aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40%.

Function:
GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.

Subunit:
Homooligomer. Interacts (via N-terminal region) withMAP4K4 (via CNH regulatory domain). Interacts with REEP5, RTN3 andRTN4 (via the transmembrane region). Interacts with SPAST;interaction is direct. May interact with TMED2. Interacts withREEP1.

Subcellular Location:
Endoplasmic reticulum membrane. Golgi apparatus membrane. Cell projection > axon.

Tissue Specificity:
Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level).

DISEASE:
Defects in ATL1 are the cause of spastic paraplegia autosomal dominant type 3 (SPG3) [MIM:182600]; also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.

Similarity:
Belongs to the GBP family. Atlastin subfamily.

Database links:

Entrez Gene: 51062 Human

Entrez Gene: 73991 Mouse

Entrez Gene: 362750 Rat

Entrez Gene: 535424 Cow

Omim: 606439 Human

SwissProt: Q58D72 Cow

SwissProt: Q8WXF7 Human

SwissProt: Q8BH66 Mouse

SwissProt: Q6PST4 Rat

Unigene: 584905 Human

Unigene: 474462 Mouse

Unigene: 135117 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.m.p2b3.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产精品久久久久九九九九不卡| 97精品国产综合久久| 中文字幕亚洲一区巨区| 国产日韩欧美中文字幕在线| 久久久久成人精品免费播放寂寞少妇| 亚洲gv永久无码天堂网| 国产日韩欧美制服另类| 一区二区三区欧美日本| 亚洲中文无无码第21页| 日本不卡久久伊人麻豆传媒| 夫妻久久久久久久久了| 国产精品偷窥熟女精品视频| 国产精品一区二区三区三级天堂| 亚洲精品国产成人99久久6| 久久久久国产精品熟女蜜臀| 人妻少妇精品视频无码专区| 亚洲AV综合色一区二区三区| 欧美日韩一区二区三区自拍| 一区二区三区精品99久久| 国产精品亚洲А∨天堂网不卡| 豆国产98在线观看亚洲| 亚洲国产精品久久久久网站| 中文字幕一区二区三区免费看| 国产一级二级三级在线观看| 97久久人人超碰国产精品| 久久这里精品国产99丫e6| 极品少妇欧美一区二区| 国产视频网站在线不卡| 久久国产成人高清精品亚洲| 日韩精品久久理论片| 亚洲欧美一区二区久久| 亚洲永久精品国产来久精品| 日韩一二三区中文字幕在线视频精品| 夫妻久久久久久久久了| 成人网站在线进入爽爽爽| 亚洲精品欧美日韩专区| 日本电影三级一区二区三区| 日本精品最新字幕一区二区| 国产在线观看一区视频| 九九免费观看精品视频| 日韩一二三区中文字幕在线视频精品|