mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产亚洲精品久久久久久床戏,久久久久久久久久久久久久艹,亚洲伊人婷婷丁香开心久久
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-SPG21/Gold Conjugated antibody (bs-11785R-Gold)
~~~促銷,代碼KT202502A~~~
~~~促銷,代碼KT202502B~~~
訂購熱線:400-901-9800
訂購郵箱:sales@m.p2b3.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@m.p2b3.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-11785R-Gold
英文名稱 Rabbit Anti-SPG21/Gold Conjugated antibody
中文名稱 膠體金標記的痙攣性截癱相關(guān)蛋白21抗體
別    名 Acid cluster protein 33; ACP33; BM019; BM-019; GL010; MAST; Maspardin; Spastic paraplegia 21 autosomal recessive Mast syndrome protein; SPG21 antibody; SPG21_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細胞生物  免疫學  神經(jīng)生物學  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPG21
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Maspardin is a 308 amino acid cytoplasmic protein that is widely expressed. Belonging to the AB hydrolase superfamily, Maspardin colocalizes with CD4 on endosomal/trans-Golgi network. It is thought that Maspardin may act as a negative regulatory factor in CD4-dependent T-cell activation. Defects in the gene encoding Maspardin are the result of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), an autosomal recessive neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. The gene encoding Maspardin is encoded by human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.

Function:
Defects in SPG21 are the cause of Mast syndrome, an autosomal recessive hereditary spastic paraplegia with dementia and other CNS abnormalities (SPG21). Present at high frequency among the Old Order Amish. Subtle childhood abnormalities may be present, but the main features develop in early adulthood. The disease is slowly progressive, and cerebellar and extrapyramidal signs are also found in patients with advanced disease. Patients have a thin corpus callosum and white matter abnormalities. The protein encoded by this gene was identified by a two hybrid screen using CD4 as the bait. It binds to the hydrophobic C terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4.

Subunit:
Interacts with CD4. Interacts with ALDH16A1.

Subcellular Location:
Cytoplasm; cytosol. Membrane; peripheral membrane protein.

Tissue Specificity:
Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level).

DISEASE:
Defects in SPG21 are the cause of spastic paraplegia autosomal recessive type 21 (SPG21) [MIM:248900]; also known as Mast syndrome. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG21 is associated with dementia and other central nervous system abnormalities. Subtle childhood abnormalities may be present, but the main features develop in early adulthood. The disease is slowly progressive, and cerebellar and extrapyramidal signs are also found in patients with advanced disease. Patients have a thin corpus callosum and white-matter abnormalities.

Similarity:
Belongs to the AB hydrolase superfamily.

Database links:
UniProtKB/Swiss-Prot: Q9NZD8.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.m.p2b3.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
啊啊不要你那痛死爽死了直播一区| 精品麻豆亚洲欧美| 欧美日韩久久久一区二区三区| 一区二区三区中文字幕免费在线| 毛片日产av一区二区三区四区| 日韩欧美一级特黄大片欧| 8050午夜三级的全黄| 黄色三极片在线观看| 色橹橹欧美在线观看视频高清免费| 久久久国产精品亚洲无码| 大胸瑟瑟黑丝午夜| 加勒比在线不卡一区二区观看| 欧美一级特黄大片在线看| 中文字幕在线观一二三区| 亚洲一区二区三区日本在线| 欧美精品一区二区三区四区五区| 在线免费观看一区二区三区| 国产成人精品免费视频全| 日日狠狠久久888av| 二次元男生操女生屁眼爽| 精品免费福利片国产| 大鸡巴干小逼视频| 色噜噜人妻丝袜中文字幕| 大鸡吧老外操中国逼| 久久久精品国产乱码内射| 美女张开腿让男人桶91| 欧美精品一区二区三区四区五区| 黑人猛操日本美女| 插女生那个的视频| 丁香社区五月在线视频久| 777米奇在线视频无码| 在线看免费无码a片视频| 亚洲一区二区三区四区国产| 白虎嫩穴抠逼高潮| 69国产精品久久久久久人| 韩国女主播一区二区视频| 国产一区二区三区三级88| 中文字幕亚洲欧美精品一区二区| 白丝袜子宫啊啊啊不要了| 美国毛片亚洲社区成人看| 中文字幕在线观看第二页|