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Rabbit Anti-Visfatin/AP Conjugated antibody (bs-0273R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0273R-AP
英文名稱 Rabbit Anti-Visfatin/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的內(nèi)脂素/內(nèi)臟脂肪素/前B細(xì)胞克隆增強(qiáng)因子1抗體
別    名 pre-B-cell colony enhancing factor 1 transcript variant 2; PBEF1 protein; 1110035O14Rik; AI314458; AI480535; NAmPRTase; Pbef; Pbef1; PBEF1; NAMPT_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  糖尿病  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Monkey, )
產(chǎn)品應(yīng)用 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Visfatin-2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011].

Function:
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway.

Subunit:
Homodimer.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.

Similarity:
Belongs to the NAPRTase family.

Database links:

Entrez Gene: 10135 Human

Entrez Gene: 59027 Mouse

Entrez Gene: 297508 Rat

Omim: 608764 Human

SwissProt: P43490 Human

SwissProt: Q99KQ4 Mouse

SwissProt: Q80Z29 Rat

Unigene: 489615 Human

Unigene: 202727 Mouse

Unigene: 203508 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

一種新的脂肪因子-visfatin (前B細(xì)胞克隆增強(qiáng)因子-2)是新近發(fā)現(xiàn)的主要由人和小鼠內(nèi)臟脂肪組織分泌的一種脂肪細(xì)胞因子,其結(jié)構(gòu)與pre-B細(xì)胞集落增強(qiáng)因子相似.它能夠發(fā)揮類似胰島素的作用,與Ⅱ型糖尿病相關(guān)聯(lián),降低血糖,促進(jìn)糖攝取,可結(jié)合并活化胰島素受體,激活胰島素信號通路.內(nèi)臟脂肪因子-Visfatin與肥胖密切相關(guān)并能夠促進(jìn)脂肪細(xì)胞的分化,還能促進(jìn)血管平滑肌細(xì)胞成熟.
Visfatin的表達(dá)受炎癥反應(yīng)因子和多種激素的調(diào)節(jié).PBEF-1可能是聯(lián)系機(jī)體糖脂代謝的重要分子,它的發(fā)現(xiàn)可為揭示糖尿病與肥胖的發(fā)生發(fā)展機(jī)制提供新的研究思路,為代謝綜合征的治療提供新方案.
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