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Rabbit Anti-phospho-IL-1R1(Tyr496)/Cy5.5 Conjugated antibody (bs-5394R-Cy5.5)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5394R-Cy5.5
英文名稱1 Rabbit Anti-phospho-IL-1R1(Tyr496)/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標(biāo)記的磷酸化白介素1受體1抗體
別    名 IL1 Receptor I (phospho Y496); Antigen CD121a; CD121 antigen-like family member A; CD121A; CD121a antigen; D2S1473; IL 1; IL 1R 1; IL 1R alpha; IL 1RT1; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; IL1 inhibitor; IL1R; IL1R1; IL1R1_HUMAN; IL1RA; IL1RN; IL1RT1; Interleukin 1 receptor alpha type 1; Interleukin 1 receptor antagonist protein (IRAP); Interleukin 1 receptor type I; Interleukin receptor 1; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; Interleukin-1 receptor type I; P80.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 心血管  免疫學(xué)  干細(xì)胞  淋巴細(xì)胞  t-淋巴細(xì)胞  細(xì)胞因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Dog, Pig, Horse, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human IL-1R1 around the phosphorylation site of Tyr496
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II(IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.

Function:
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Subunit:
The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Cell membrane (Probable). Secreted.

Post-translational modifications:
A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).

Similarity:
Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain.

Database links:

Entrez Gene: 3554 Human

Entrez Gene: 16177 Mouse

Entrez Gene: 25663 Rat

Omim: 147810 Human

SwissProt: P14778 Human

SwissProt: P13504 Mouse

SwissProt: Q02955 Rat

Unigene: 516249 Human

Unigene: 701982 Human

Unigene: 896 Mouse

Unigene: 9758 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IL-1RⅠ屬于新的信號(hào)受體家族Toll信號(hào)轉(zhuǎn)導(dǎo)通路蛋白,IL-1RⅠ在免疫和炎癥反應(yīng)的研究中占重要地位,是在很多感染 、炎癥性致病機(jī)制中起決定性作用的細(xì)胞因子,幾乎可作用于全身各種細(xì)胞,IL-1 與IL-1R1的結(jié)合可導(dǎo)致大量與免疫反應(yīng)和炎癥相關(guān)基因的表達(dá) ,包括細(xì)胞因子、細(xì)胞因子受體、急性期反應(yīng)物、生長(zhǎng)因子、胞外基質(zhì)、粘附分子等。IL-1R1/NF-κB信號(hào)通路是機(jī)體免疫反應(yīng)中十分重要的組成部分。白介素1受體I型 Interleukin 1 receptor I(IL-1RI)
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