| 產(chǎn)品編號 |
bs-1074R-Gold |
| 英文名稱 |
Rabbit Anti-Nrf2/Gold Conjugated antibody
|
| 中文名稱 |
膠體金標(biāo)記的核因子2相關(guān)因子2抗體 |
| 別 名 |
Nuclear factor-E2 related factor2; Nrf-2; HEBP1; NF E2 related factor 2; NFE2 related factor 2; NFE2L2; Nrf 2; Nuclear factor erythroid 2 related factor 2; Nuclear factor erythroid derived 2 like 2; NF2L2_HUMAN. |
| 規(guī)格價(jià)格 |
100ul/2980元
購買 大包裝/詢價(jià) |
| 說 明 書 |
100ul（10nm 15nm 35nm）
|
| 研究領(lǐng)域 |
腫瘤 免疫學(xué) 染色質(zhì)和核信號 合成與降解 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Human, Mouse, Rat,
(predicted: Chicken, Dog, Cow, Horse, Rabbit, )
|
| 產(chǎn)品應(yīng)用 |
IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
68kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
0.4mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human Nrf2 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 |
Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Function:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Subunit:
Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.
Subcellular Location:
Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Tissue Specificity:
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
Post-translational modifications:
Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
Similarity:
Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain.
Database links:
Entrez Gene: 4780 Human
Omim: 600492 Human
SwissProt: Q16236 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轉(zhuǎn)錄調(diào)節(jié)因子（Transcriptin Regulators）
核細(xì)胞系因子2相關(guān)因子Nrf2，是一種對氧化還原反應(yīng)敏感的轉(zhuǎn)錄因子，可以通過正向促進(jìn)基因的表達(dá)，來轉(zhuǎn)錄翻譯產(chǎn)生一些抗氧化物，行使著異化解毒的酶類和藥物的高效外排泵作用。
有學(xué)者認(rèn)為：核因子2相關(guān)因子2蛋白在保護(hù)細(xì)胞免受環(huán)境毒性物質(zhì)影響方面發(fā)揮著極其重要的作用，它指導(dǎo)某些基因促進(jìn)細(xì)胞的防御工事，同時(shí)也刺激某些重要解毒酶對毒性物質(zhì)，如黃曲霉素的解毒和排毒作用。
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