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Rabbit Anti-GIMAP5/BF488 Conjugated antibody (bs-8271R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-8271R-BF488
英文名稱1 Rabbit Anti-GIMAP5/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的GTP酶IMAP家族成員5抗體
別    名 HIMAP3; IAN4; IAN4L1; IAN5; IMAP3; FLJ11296; GIMAP 5; GTPase IMAP family member 5; GTPase, IMAP family member 5; immunity-associated nucleotide 5; hIAN5; IAN 5; Immune associated nucleotide 4 like 1; Immunity associated nucleotide 4 like 1 protein; Immunity associated protein 3; GIMA5_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  t-淋巴細(xì)胞  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from huam GIMAP5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
GIMAP5, also known as IAN5, IAN4L1 (immunity-associated nucleotide 4-like 1 protein), IAN4, IMAP3, HIMAP3 or IROD, is a 307 amino acid single-pass type IV membrane protein of the mitochondrial outer membrane. A member of the GTP-binding superfamily and the immuno-associated nucleotide (IAN) subfamily, GIMAP5 plays a role in T-cell survival and mitochondrial integrity. GIMAP5 is highly expressed in CD4 and CD8-positive T-cells and monocytes, as well as B-lymphocyte-derived neoplasms. GIMAP5 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 7q36.1. Defects in the GIMAP5 gene are associated with systemic lupus erythematosus.

Function:
Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity).

Subcellular Location:
Mitochondrion outer membrane; Single-pass type IV membrane protein (By similarity). Lysosome.

Tissue Specificity:
Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T-cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms.

Similarity:
Belongs to the IAN GTP-binding protein family.

Database links:
UniProtKB/Swiss-Prot: Q96F15.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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