| 產(chǎn)品編號(hào) | bs-0426R-APC |
| 英文名稱 | Rabbit Anti-Myelin-oligodendrocyte glycoprotein/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的髓鞘少樹突膠質(zhì)細(xì)胞糖蛋白抗體 |
| 別 名 | myelin oligo-dendrocyte glycoprotein-MOG; MGC26137; MOG alpha 6; MOG; MOGIG2; Myelin oligodendrocyte glycoprotein; MOG_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 細(xì)胞凋亡 細(xì)胞粘附分子 細(xì)胞膜蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Pig, Guinea Pig, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Guinea pig MOG(35-55) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ. Function: Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Subunit: Homodimer. May form heterodimers between the different isoforms. Subcellular Location: Cell membrane; Multi-pass membrane protein (Potential). Tissue Specificity: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes. DISEASE: Defects in MOG are the cause of narcolepsy type 7 (NRCLP7) [MIM:614250]. Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 4340 Human Entrez Gene: 17441 Mouse Omim: 159465 Human SwissProt: Q16653 Human SwissProt: Q61885 Mouse Unigene: 141308 Human Unigene: 210857 Mouse Unigene: 9687 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 該蛋白與脊髓多發(fā)性硬化有直接關(guān)系。 有學(xué)者認(rèn)為：用免疫組織化學(xué)方法所顯示軸突周圍少樹突膠質(zhì)細(xì)胞糖蛋白的異常先于髓鞘破壞。主張病變主要在少樹突膠質(zhì)細(xì)胞的超微結(jié)構(gòu)方面，這方面還有待于深入研究。 |
