| 產(chǎn)品編號(hào) |
bs-0322R-HRP |
| 英文名稱 |
Rabbit Anti-AEBP1/HRP Conjugated antibody
|
| 中文名稱 |
辣根過(guò)氧化物酶標(biāo)記的脂肪細(xì)胞增強(qiáng)結(jié)合蛋白1 |
| 別 名 |
AE binding protein 1; ACLP; Adipocyte enhancer binding protein 1; AEBP 1; AEBP1; Aortic carboxypeptidase like protein ACLP;Aortic carboxypeptidase like protein; FLJ33612; AEBP1_HUMAN; Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein. |
| 規(guī)格價(jià)格 |
100ul/2980元
購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) |
100ul
|
| 研究領(lǐng)域 |
免疫學(xué) 染色質(zhì)和核信號(hào) 轉(zhuǎn)錄調(diào)節(jié)因子 結(jié)合蛋白 |
| 抗體來(lái)源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
(predicted: Human, Mouse, Rat, )
|
| 產(chǎn)品應(yīng)用 |
WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
128/80kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human AEBP1 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013].
Function:
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
Subunit:
Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. May interact with calmodulin. Binds to DNA in vitro.
Subcellular Location:
Isoform 1: Secreted.
Isoform 2: Cytoplasm (Probable). Nucleus (Probable).
Tissue Specificity:
Expressed in osteoblast and visceral fat.
Post-translational modifications:
Phosphorylated by MAPK1 in vitro.
Similarity:
Belongs to the peptidase M14 family.
Contains 1 F5/8 type C domain.
Database links:
Entrez Gene: 165 Human
Omim: 602981 Human
SwissProt: Q14113 Human
Unigene: 439463 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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