| 產(chǎn)品編號(hào) | bs-0406R-BF488 |
| 英文名稱1 | Rabbit Anti-IGFBP5/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的胰島素樣生長因子結(jié)合蛋白5抗體 |
| 別 名 | IBP 5; IBP5; IGF binding protein 5; IGF BP5; Insulin Like Growth Factor Binding Protein 5; IBP5_HUMAN; Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 糖尿病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IGFBP5(101-200aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: IGFBP5 is one of a family of proteins that bind to insulin-like growth factors (IGFs). IGFBP5 is a multifunctional protein which acts not only as a traditional binding protein but also functions as a growth factor independent of IGFs to stimulate bone formation. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGFII. IGFBP5 is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGFI on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development. Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Subcellular Location: Secreted. Tissue Specificity: Osteosarcoma, and at lower levels in liver, kidney and brain. Similarity: Contains 1 IGFBP N-terminal domain. Contains 1 thyroglobulin type-1 domain. Database links: Entrez Gene: 3488 Human Entrez Gene: 16011 Mouse Omim: 146734 Human SwissProt: P24593 Human SwissProt: Q07079 Mouse Unigene: 607212 Human Unigene: 405761 Mouse Unigene: 1593 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 生長因子和激素（ Growth Factor and Hormones） IGFBP5胰島素樣生長因子結(jié)合蛋白5(IGFBP-5)是一種可以與胰島素樣生長因子(IGFs)結(jié)合的分泌性蛋白,其通過IGFs調(diào)節(jié)細(xì)胞的生長、分化、凋亡、黏附和運(yùn)動(dòng),IGFBP-5與IGFs結(jié)合可以調(diào)節(jié)IGFs與IGF-I型受體間的相互作用,改變其促有絲分裂效應(yīng)、凋亡抑制效應(yīng)和促細(xì)胞運(yùn)動(dòng)作用。 有人認(rèn)為：由于造骨細(xì)胞能表達(dá)與IGF-1受體截然不同的IGFBP-5受體，IGFBP-5本身也是一種生長因子，能夠不依賴IGF-I獨(dú)立作用來調(diào)節(jié)骨代謝。 |
