mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
7777久久精品一区二区,亚洲一区二区免费在线电影
Rabbit Anti-GLP-1 (7-36)/APC Conjugated antibody (bs-0038R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@m.p2b3.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@m.p2b3.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0038R-APC
英文名稱1 Rabbit Anti-GLP-1 (7-36)/APC Conjugated antibody
中文名稱 APC標(biāo)記的胰高血糖素樣肽-1抗體
別    名 GCG; GLP 1; glucagon; Glucagon like peptide 1; GRPP; GLP-1(7-36); GLP-1(7-37); Oxyntomodulin; OXM; OXY; GLUC_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  糖尿病  內(nèi)分泌病  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GLP-1 (7-36)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq].

Function:
Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis.
GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.
Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.
Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.

Subcellular Location:
Secreted.

Tissue Specificity:
Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.

Post-translational modifications:
Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.

Similarity:
Belongs to the glucagon family.

Database links:

Entrez Gene: 2641 Human

Entrez Gene: 14526 Mouse

Entrez Gene: 24952 Rat

Omim: 138030 Human

SwissProt: P01275 Human

SwissProt: P55095 Mouse

SwissProt: P06883 Rat

Unigene: 516494 Human

Unigene: 45494 Mouse

Unigene: 54383 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胰高血糖素(Glucagon)在糖代謝和體內(nèi)平衡中起重要作用,通過釋放糖原和糖酵解調(diào)節(jié)血糖。作為反調(diào)節(jié)激素的胰島素,當(dāng)血糖升高時,胰島素可誘導(dǎo)低血糖。胰高血糖素樣肽-1(Glucagon-like peptide-1, GLP-1)是一個具有強(qiáng)的刺激糖依賴的胰島素釋放的肽,在胃運動性和抑制血糖水平上起重要作用。還可能參與外周組織糖的控制,不依賴胰島素的作用。具有促進(jìn)腸上皮生長等作用。GLP-1屬于胰高血糖素家族成員。
版權(quán)所有 2004-2026 www.m.p2b3.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产成人亚洲综合91精品首页| 色婷婷狠狠久久综合五月| 国产精品不卡a∨在线观看| 欧美加勒比一区二区三区| 欧美日韩精品一区二区三区激情在线| 国产精品亚洲欧美日韩一区在线| 日本免费一区二区在线观看| 亚洲男人天堂成人网| 免费在线观看一本视频| 欧美亚洲综合一区色婷婷| 亚洲男人天堂成人网| 超碰人人在线免费观看| 中文亚洲欧美日韩国产| 国产三级电影精品麻豆| 久久99国产精品综合| 日韩欧美一级视频观看| 人与嘼一区二区三区| 极品少妇欧美一区二区| 99久久国产亚洲精品美女| 中文字幕人妻乱一区二区三区| 日本成人在线不卡视频| 鼻子里天天有黄色鼻屎| 久久久久亚洲av毛片大| 欧美日韩制服丝袜中文字幕| 成年女人都爱看的毛片| 一区二区不卡99精品日韩| 亚洲精品一区二区三区中文字幕| 国产精品久久久久99999| 国产精品久久久久久福利69| 麻豆理论片在线观看| 人妻夜夜爽天天爽精品三区| 日本在线观看黄视频| 亚洲综合色婷婷久久| 国产一级二级三级精品| 丰满少妇高潮一区二区| 亚洲精品国产第一区三区| 久久久精品熟女亚洲av麻豆| 91国产精品免费观看| 超碰人人在线免费观看| 久久久久久久久久久极品| 93国产精品久久久久久|