| 產(chǎn)品編號 | bs-0591R-BF350 |
| 英文名稱 | Rabbit Anti-DR4/BF350 Conjugated antibody |
| 中文名稱 | BF350標(biāo)記的死亡受體4抗體 |
| 別 名 | Apo 2; Apo2; CD 261; CD261; CD261 antigen; Cytotoxic ligand TRAIL receptor; Cytotoxic TRAIL receptor; Death receptor 4; DR 4; DR4; MGC9365; NF related apoptosis-inducing ligand receptor 1; T10A; TNF related apoptosis inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR 1; TRAILR1; Tumor necrosis factor receptor superfamily member 10a; Tumor necrosis factor receptor superfamily member 10A precursor; TR10A_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Rat, |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DR4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor 1(TRAIL R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF kB activation in many tissues and cells. Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Subunit: Can interact with TRADD and RIPK1. Interacts with ARAP1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells. Similarity: Contains 1 death domain. Contains 3 TNFR-Cys repeats. Database links: Entrez Gene: 8797 Human Omim: 603611 Human SwissProt: O00220 Human Unigene: 213467 Human Unigene: 591834 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
