mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
91人妻人人做人碰人人蜜臀,夜鲁鲁鲁夜夜综合视频欧美
Rabbit Anti-DISC1 (CT)/BF594 Conjugated antibody (bs-0430R-BF594)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@m.p2b3.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@m.p2b3.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0430R-BF594
英文名稱 Rabbit Anti-DISC1 (CT)/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的DISC1 C端抗體
別    名 disrupted in schizophrenia1; C1orf136; KIAA0457; RP4-730B13.1; SCZD9; DISC1; DISC1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 92kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DISC1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

Function:
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.

Subunit:
Interacts with NDEL1. Interacts with CCDC88A (via C-terminus); the interaction is direct. Interacts with GSK3B. Interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. Interaction with microtubules may be mediated in part by TRAF3IP1. Interacts (via C-terminal) with PCNT. Interacts with CHCHD6.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. ytoplasm, cytoskeleton, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome. Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome.

Tissue Specificity:
Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter.

DISEASE:
Note=A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1.
Schizophrenia 9 (SCZD9) [MIM:604906]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Database links:

Entrez Gene: 27185 Human

Omim: 605210 Human

SwissProt: Q9NRI5 Human

Unigene: 13318 Human

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

DISC1基因是蛋白質(zhì)復(fù)合體中的一部分,它對(duì)大腦皮層發(fā)育過程中細(xì)胞的正常運(yùn)動(dòng)很重要。
DISC-1基因的變異增加了患精神分裂癥的風(fēng)險(xiǎn)。研究人員發(fā)現(xiàn),抑制老鼠的DISC1活性則改變了動(dòng)物大腦的發(fā)育,引起了大腦皮層輕微的變異,而在對(duì)精神分裂癥病人進(jìn)行尸檢時(shí)在其大腦中見到了此變化。研究人員還發(fā)現(xiàn)將DISC1與對(duì)大腦發(fā)育和調(diào)節(jié)神經(jīng)傳遞素水平很重要的分子信號(hào)路徑聯(lián)系起來,精神病患者的神經(jīng)傳遞素水平往往是不正常的。
新研究顯示DISC1蛋白質(zhì)與一個(gè)叫PDE4B的酶相互作用,而影響信號(hào)傳遞分子cAMP的活性。這個(gè)信號(hào)傳遞系統(tǒng)過去在其它試驗(yàn)系統(tǒng)中被發(fā)現(xiàn)與學(xué)習(xí)、記憶、以及情緒有關(guān),這與該系統(tǒng)中的變化可能促成精神分裂癥是一致的。
版權(quán)所有 2004-2026 www.m.p2b3.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲国产成久久成人综合一区| 欧美亚洲综合一区二区三区| 大鸡巴狂插嫩逼视频| 黄色录像片操大逼的| 亚洲欧美日韩精品一区二区| 男人大鸡巴操小鲜肉视频| 在线观看国产日韩欧美一区二区| 爆操大奶子美女视频| 男人操女人下面国产剧情| 小美女淫荡的视频| 娇嫩的被两根粗大的np| 性色av少妇一区二区三区多人| 欧美猛男一区二区三区快播| 国产伦精品一区二区三区视频抖音| 亚洲男性天堂一区二区三区| 亚洲免费福利视频| 正在播放 国产精品推荐| 很黄很爽的免费视频大全| 大阴茎交于大阴户黄片视频| 免费看黑人操逼视频| 国产成人无码91精品一区| 亚洲一区二区三区精品日韩| 熟女菊蕾老妇俱乐部视频| 普通话大屌操小穴| 中文字幕在线观看第二页| 亚洲v国产v天堂a无码| 普通话大屌操小穴| 97精品人妻人人做人人爽| 丁香婷婷亚洲六月综合色| 肏亚洲女人小骚逼| 国产蜜月精品高清一区二区三区| 男人插女人视频软件| 久久久久亚洲精品无码系列| 欧美人与性动交b欧美精品| 精品美女久久久久久嘘嘘| 中文字幕在线观看第二页| 美女逼男逼小穴小骚下载| 日本免费一区二区在线| 青青河边草直播免费观看| 国产激情内射免费精品| 亚洲一区二区三区四区国产|