mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯系我們
91久久精品国产91性色,99re久久这里只有精品6亚洲,激情五月婷婷综合色
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-SIRT1(Ser47)/Cy7 Conjugated antibody (bs-3393R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@m.p2b3.cn
訂購QQ:  400-901-9800
技術支持:techsupport@m.p2b3.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3393R-Cy7
英文名稱1 Rabbit Anti-Phospho-SIRT1(Ser47)/Cy7 Conjugated antibody
中文名稱 Cy7標記的磷酸化沉默調節(jié)蛋白1抗體
別    名 75SirT1; BA57G10.4; hSIR2; hSIRT1; NAD dependent deacetylase SIRT1; NAD dependent deacetylase sirtuin 1; NAD dependent deacetylase sirtuin 2; Silent mating type information regulation 2; OTTHUMP00000198111; OTTHUMP00000198112; SIR2 like 1; SIR2 like protein 1; SIR2-like protein 1; Regulatory protein SIR2 homolog 1; SIR1_HUMAN; SIR2ALPHA; SIR2alpha protein; SIR2L1; SIR2L2; SIRT 1; SIRT-1; Sirt1; SIRT1 Sir2 like proteins (siruitins) type 1; SIRT1: sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); SirtT1 75 kDa fragment; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae);Sirtuin 1; sirtuin; Sirtuin type 1; Sirtuin type 2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 細胞生物  免疫學  染色質和核信號  微生物學  新陳代謝  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Dog, Pig, Rabbit, )
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 58/81kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human SirT1 around the phosphorylation site of Ser47
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Function:
SirtT1 75 kDa fragment: catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly.

Subunit:
Found in a complex with PCAF and MYOD1 (By similarity). Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. Interacts with HES1, HEY2 and PML. Interacts with RPS19BP1/AROS. Interacts with KIAA1967/DBC1 (via N-terminus); the interaction disrupts the interaction between SIRT1 and p53/TP53. Interacts with SETD7; the interaction induces the dissociation of SIRT1 from p53/TP53 and increases p53/TP53 activity. Interacts with MYCN, NR1I2, CREBZF, TSC2, TLE1, FOS, JUN, NR0B2, PPARG, NCOR, IRS1, IRS2 and NMNAT1. Interacts with HNF1A; the interaction occurs under nutrient restriction. Interacts with SUZ12; the interaction mediates the association with the PRC4 histone methylation complex which is specific as an association with PCR2 and PCR3 complex variants is not found. Interacts with HIV-1 tat.

Subcellular Location:
Nucleus, PML body. Cytoplasm. Note=Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm.
SirtT1 75 kDa fragment: Cytoplasm. Mitochondrion.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Methylated on multiple lysine residues; methylation is enhanced after DNA damage and is dispensable for deacetylase activity toward p53/TP53.
Phosphorylated. Phosphorylated by STK4/MST1, resulting in inhibition of SIRT1-mediated p53/TP53 deacetylation. Phosphorylation by MAPK8/JNK1 at Ser-27, Ser-47, and Thr-530 leads to increased nuclear localization and enzymatic activity. Phosphorylation at Thr-530 by DYRK1A and DYRK3 acivates deacetylase activity and promotes cell survival. Phosphorylation by mammalian target of rapamycin complex 1 (mTORC1) at Ser-47 inhibits deacetylation activity. Phosphorylated by CaMK2, leading to increased p53/TP53 and NF-kappa-B p65/RELA deacetylation activity (By similarity). Phosphorylation at Ser-27 implicating MAPK9 is linked to protein stability. There is some ambiguity for some phosphosites: Ser-159/Ser-162 and Thr-544/Ser-545.
Proteolytically cleaved by cathepsin B upon TNF-alpha treatment to yield catalytic inactive but stable SirtT1 75 kDa fragment (75SirT1).
S-nitrosylated by GAPDH, leading to inhibit the NAD-dependent protein deacetylase activity (By similarity).

Similarity:
Belongs to the sirtuin family.
Contains 1 deacetylase sirtuin-type domain.

Database links:

Entrez Gene: 23411 Human

Entrez Gene: 93759 Mouse

Entrez Gene: 309757 Rat

Omim: 604479 Human

SwissProt: Q96EB6 Human

SwissProt: Q923E4 Mouse

Unigene: 369779 Human

Unigene: 351459 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

在Sirtuin蛋白家族中,sirtuin 1參與多種新陳代謝活動,包括DNA的自我保護和修復,抑制脂質過氧化積累,抑制其他細胞凋亡相關基因的表達以及和細胞壽命相關的活動。限制攝入的熱量可以加強SIRT1的表達,從而延長了壽命。
版權所有 2004-2026 www.m.p2b3.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
国内精品国产三级国产av万事达| 久久久久成人精品免费播放寂寞少妇| 欧美色欧美亚洲另类在线视频| 国产av一区二区三区久久久久| 一区二区三区久久99精品| 亚洲综合网无码中文字幕| 久久久成人国产精品麻豆| 国产精品不卡在线视频| 亚洲精品日韩在线丰满| 欧洲在线观看亚洲三区| 好看的福利电影在线| 91午夜精品亚洲一区二区三区| 丰满少妇人妻久久久久久| 超碰人人在线免费观看| 亚洲另类欧美在线中文字幕不卡| 亚洲av熟女少妇一区二区三区| 久久99国产精品综合| 亚成区一区二区人妻熟女| 久久精一区二区三区| 国产精品欧美激情青草| 国产高新无码在线观看| 韩漫漫画在线免费看视频| 欧美大片免费看片入口| 午夜在线观看视频在线观看| 国产欧美精品区一区二区三区竹菊| 日本伊人久久精品视频| 日本一区二区三区综合| 亚洲区一区二区三区视频| 亚洲综合色婷婷久久| 日韩精品一区二区三区在线| 99久久无色码中文字幕人妻| 欧美日韩一区二区乱码| 久久久久久久久久久极品| 人妻熟女的高跟丝袜艳遇| 日韩一区二区三区日韩精品| 日本一区二区三区人妻视频| 国产白嫩精品久久久| 午夜精品人妻一区二区三区| 精品国产污免费网站入口| 日本阿v不卡在线观看视频| 神马午夜久久久久久|