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Rabbit Anti-TLR11/Gold Conjugated antibody (bs-2694R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2694R-Gold
英文名稱 Rabbit Anti-TLR11/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的Toll樣受體11抗體
別    名 Toll like receptor 11; Gm287; MGC129352; MGC129353; RGD1564460; TLR11_MOUSE.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 免疫學(xué)  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Mouse, Rat, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 99kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse TLR11
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Toll like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system.

Function:
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Subunit:
Binds MYD88 via their respective TIR domains. Interacts with HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the Toll-like receptor family.
Contains 10 LRR (leucine-rich) repeats.
Contains 1 TIR domain.

Database links:

Entrez Gene: 239081 Mouse

SwissProt: Q6R5P0 Mouse

Unigene: 291512 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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