| 產(chǎn)品編號(hào) | bs-2444R-BF488 |
| 英文名稱 | Rabbit Anti-Pleiotrophin/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的多效生長因子抗體 |
| 別 名 | pleiotrophin; HARP; HBBM; HBGAM; HBGF8; HBNF; HBNF1; Heparin Binding Growth Factor 8; Heparin binding neurite outgrowth promoting factor 1; heparin-binding growth associated molecule; NEGF1; Neurite Growth Promoting Factor 1; OSF-1; osteoblast-specific factor; PTN; PTN_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長因子和激素 細(xì)胞骨架 細(xì)胞外基質(zhì) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 15kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PTN |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Pleiotrophin is a heparin-binding growth factor involved in the differentiation and proliferation of neuronal tissue during embryogenesis, and also secreted by melanoma and breast carcinoma cells. Pleiotrophin exhibits mitogenic and angiogenic properties and has been shown to influence the vascular supply, expansion and metastasis of tumour cells. Function: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. Subunit: Interacts with ALK and NEK6. Subcellular Location: Secreted. Tissue Specificity: Osteoblast and brain. Post-translational modifications: Phosphorylated by NEK6. Similarity: Belongs to the pleiotrophin family. Database links: Entrez Gene: 5764 Human Entrez Gene: 19242 Mouse Omim: 162095 Human SwissProt: P21246 Human SwissProt: P63089 Mouse Unigene: 371249 Human Unigene: 279690 Mouse Unigene: 1653 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 多效生長因子(pleiotrophin）是一種分泌性的生長因子,具有促進(jìn)腫瘤細(xì)胞的增殖與遷移，對(duì)腫瘤血管的生成有促進(jìn)作用。 |
