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Rabbit Anti-LCMV RING finger protein Z/Gold Conjugated antibody (bs-6946R-Gold)
訂購熱線:400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-6946R-Gold
英文名稱1 Rabbit Anti-LCMV RING finger protein Z/Gold Conjugated antibody
中文名稱 膠體金標記的淋巴細胞性脈絡叢腦膜炎病毒蛋白抗體
別    名 Lymphocytic choriomeningitis virus; Z_LYCVA; Z; RING finger protein Z; Protein Z; Zinc-binding protein.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 微生物學  細菌及病毒  淋巴細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 10kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from LCMV RING finger protein Z
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
LCMV is a member of the family Arena-viridae that causes a rodent-borne viral infectious nonbacterial/aseptic meningitis, encephalitis or meningoencephalitis. LCMV is a reverse strand single stranded RNA virus that is naturally spread by the common house mouse. Since the virus is somewhat resistant to drying effects, humans can become infected by inhaling infectious aerosolized particles of rodent urine, feces or saliva; by ingesting food contaminated with the virus; by contamination of mucus membranes with infected body fluids; or by directly exposing cuts or other open wounds to virus-infected blood. The virus is usually only dangerous to those who are immunocompromised.

Function:
Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. Also selectively represses protein production by associating with host eIF4E.

Subunit:
Interacts with protein NP; this interaction probablydirects the encapsidated genome to budding sites. Interacts (via RING domain) with polymerase L; this interactioninhibits viral transcription and replication (By similarity).Interacts with the glycoprotein complex; this interaction plays arole in virion budding. Interacts with host eIF4E; this interactionresults in eIF4E reduced affinity for its substrate, the 5'-m7 Gcap structure. Interacts (via late-budding domain) with hostTSG101; this interaction is essential for budding and release ofviral particles. Interacts with host RPLP0; this interaction mayserve to load ribosome-like particles inside the virion. Interactswith host PML; this interaction induces PML bodies redistributionin the cytoplasm upon viral infection.

Subcellular Location:
Virion. Host cytoplasm, host perinuclearregion. Host cell membrane; Lipid-anchor; Cytoplasmic side.Note=Mainly perinuclear. During budding, associates at the innerside of the plasma membrane of infected cells.

Similarity:
Belongs to the arenaviridae Z protein family.
Contains 1 RING-type zinc finger.

Database links:
UniProtKB/Swiss-Prot: P18541

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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