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Rabbit Anti-Osteocrin/PE-Cy7 Conjugated antibody (bs-9566R-PE-Cy7)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-9566R-PE-Cy7
英文名稱1 Rabbit Anti-Osteocrin/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標記的肌肉素抗體
別    名 Musclin; OSTN; OSTN_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  干細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 3.2kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Osteocrin (83-133)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Musclin, also designated osteocrin (Ostn), shows no homology with any known genes, except that it contains two conserved sequence motifs homologous to the natriuretic peptide family. Musclin is highly expressed in cells of osteoblast lineage and in skeletal muscle tissue, where it is tightly regulated by nutritional changes. It is secreted as either a full-length precursor protein or a processed form. A novel skeletal muscle-derived secretory factor, Musclin may play a role in bone formation and be linked to glucose metabolism. Studies indicate that insulin increases Musclin expression, whereas epinephrine, isoproterenol and forskolin reduce its expression. Musclin is expressed in osteoblasts and young osteocytes. In mouse tissues, expression is bone-specific, although minimal Musclin expression is also observed in muscle, kidney, testis and heart tissues.

Function:
Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in bone.

Database links:

Entrez Gene: 344901 Human

Entrez Gene: 239790 Mouse

Entrez Gene: 360730 Rat

Omim: 610280 Human

SwissProt: P61366 Human

SwissProt: P61364 Mouse

SwissProt: Q149W1 Mouse

SwissProt: P61365 Rat

Unigene: 526794 Human

Unigene: 390880 Mouse

Unigene: 29193 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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