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Rabbit Anti-Alpha-1-Antichymotrypsin/BF350 Conjugated antibody (bs-0094R-BF350)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0094R-BF350
英文名稱1 Rabbit Anti-Alpha-1-Antichymotrypsin/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的α-1抗胰糜蛋白酶/SERPINA3抗體
別    名 Alpha 1-Antichymotrypsin; AACT-Alpha 1; AACT Alpha 1; SERPINA3; AACT; A1ACT; ACT; Alpha 1 Antichymotrypsin 1; Alpha 1 Antichymotrypsin 2; Alpha 1 Antichymotrypsin 3; Alpha 1 Antitrypsin Deficiency; Anti Elastase; Antichymotrypsin; Cell growth inhibiting gene 24/25 protein; Clade A (Alpha 1 Antiproteinase Antitrypsin); GIG24; GIG25; Growth inhibiting protein 24; Growth inhibiting protein 25; MGC88254; PI1; Protease Inhibitor 1; Serine (or Cysteine) Proteinase Inhibitor; Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase, antitrypsin) member 3; Serine (or cysteine) proteinase inhibitor clade A member 3; Serine proteinase inhibitor clade A member 3; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3; SERPINA1; SERPINA2; SERPINA3; Serpin A3; Alpha-1-antichymotrypsin His-Pro-less; AACT_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  細(xì)胞生物  神經(jīng)生物學(xué)  糖尿病  泛素  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AACT-Alpha1 N-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Alpha 1-Antichymotrypsin, a member of the serine proteinase inhibitor (serpin) family, inhibits neutrophil proteinase cathepsin G and mast cell chymases, and protects the lower respiratory tract from damage by proteolytic enzymes. It contains a reactive centre loop, which interacts with cognate proteinases, resulting in loop cleavage and a major conformational change. Recently, alpha 1-antichymotrypsin has been identified as a major constituent of the neurofibrillary plaques associated with Alzheimers disease, and in vitro studies have shown that it enhances the rate of amyloid-fibril formation. These observations and recent genetic evidence suggest that alpha 1-antichymotrypsin is important in the pathogenesis of Alzheimers disease.

Function:
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.

Subunit:
Interacts with DNAJC1.

Subcellular Location:
Secreted.

Tissue Specificity:
Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.

Similarity:
Belongs to the serpin family.

Database links:

Entrez Gene: 12 Human

Omim: 107280 Human

SwissProt: P01011 Human

Unigene: 534293 Human

Unigene: 710488 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

AACT是由神經(jīng)膠質(zhì)細(xì)胞分泌并參與淀粉樣纖維生成和沉積的一種色氨酸蛋白酶抑制劑,被認(rèn)為是Aβ肽的假性底物,與Aβ肽具有很高的親合性,可促進(jìn)Aβ肽的纖維化以生成淀粉樣沉積。
ApoE作為AD的另一種病理伴隨性物質(zhì),也可識(shí)別并與Aβ肽相結(jié)合,促進(jìn)Aβ肽沉積生成淀粉樣老年斑塊。由于AACT和ApoE在AD發(fā)病中具有共同的作用途徑,因此探討其相互作用可能是AD治療中一個(gè)新的途徑。
AACT是一種絲氨酸蛋白酶抑制劑,可以中和糜蛋白酶等酶活性的蛋白酶,存在于大多數(shù)的組織細(xì)胞、巨噬細(xì)胞以及多種胃腸道和肺部腫瘤中,但多形核白細(xì)胞中無此物質(zhì),它可以作為組織細(xì)胞瘤和良性/惡性纖維組織細(xì)胞瘤的標(biāo)志。此抗體與人的AACT反應(yīng),主要用于惡性纖維組織細(xì)胞瘤等惡性腫瘤的診斷,也可用于胃癌﹑肺癌、腎癌等腫瘤的研究。
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